Y
Yuan Xue
Researcher at Stanford University
Publications - 17
Citations - 516
Yuan Xue is an academic researcher from Stanford University. The author has contributed to research in topics: Toxoplasma gondii & DNA polymerase. The author has an hindex of 6, co-authored 17 publications receiving 374 citations. Previous affiliations of Yuan Xue include Reed College.
Papers
More filters
Journal ArticleDOI
Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion
Jing Zhou,Shi-Hao Tan,Valérie Nicolas,Chantal Bauvy,Nai-Di Yang,Jianbin Zhang,Yuan Xue,Patrice Codogno,Han-Ming Shen +8 more
TL;DR: It is found that suppression of mammalian target of rapamycin activity by starvation or two mTOR catalytic inhibitors (PP242 and Torin1), but not by an allosteric inhibitor (rapamycin), leads to activation of lysosomal function.
Journal ArticleDOI
Self-assembling manifolds in single-cell RNA sequencing data
TL;DR: This work presents the self-assembling manifold (SAM) algorithm, an iterative soft feature selection strategy to quantify gene relevance and improve dimensionality reduction, and demonstrates its advantages over other state-of-the-art methods with experimental validation in identifying novel stem cell populations of Schistosoma mansoni.
Journal ArticleDOI
A single-parasite transcriptional atlas of Toxoplasma Gondii reveals novel control of antigen expression.
TL;DR: This work applied single-cell RNA-sequencing on >5,400 Toxoplasma in both tachyzoite and bradyzoite stages using three widely studied strains to construct a comprehensive atlas of cell-cycle and asexual development, revealing hidden states and transcriptional factors associated with each developmental stage.
Journal ArticleDOI
Single-cell analysis of Schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fate.
Pengyang Li,Dania Nanes Sarfati,Yuan Xue,Xi Yu,Alexander J. Tarashansky,Stephen R. Quake,Bo Wang +6 more
TL;DR: In this article, the authors performed single-cell RNA sequencing on juvenile schistosomes and captured GSCs during de novo gonadal development, identifying a genetic program that controls the proliferation and differentiation of GSC.
Journal ArticleDOI
Differential Impacts on Host Transcription by ROP and GRA Effectors from the Intracellular Parasite Toxoplasma gondii
TL;DR: Based on comparisons of infected and U-I cells, the host’s earliest response to infection appears to be driven primarily by the injected ROPs, which appear to induce immune and cellular stress pathways.