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Shilong Yang
Researcher at Kunming Institute of Zoology
Publications - 41
Citations - 700
Shilong Yang is an academic researcher from Kunming Institute of Zoology. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 12, co-authored 31 publications receiving 479 citations. Previous affiliations of Shilong Yang include Northeast Forestry University.
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Journal ArticleDOI
Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models
Shilong Yang,Yao Xiao,Yao Xiao,Di Kang,Di Kang,Jie Liu,Jie Liu,Yuan Li,Yuan Li,Eivind A. B. Undheim,Julie K. Klint,Mingqiang Rong,Ren Lai,Glenn F. King +13 more
TL;DR: The identification of µ-SLPTX-Ssm6a, a unique 46-residue peptide from centipede venom that potently inhibits NaV1.7 with an IC50 of ∼25 nM is established, which might be suitable for treating a wide range of human pain pathologies.
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Centipedes subdue giant prey by blocking KCNQ channels
Lei Luo,Bowen Li,Bowen Li,Sheng Wang,Fangming Wu,Xiaochen Wang,Ping Liang,Rose Ombati,Rose Ombati,Junji Chen,Xiancui Lu,Xiancui Lu,Jianmin Cui,Qiumin Lu,Longhua Zhang,Longhua Zhang,Ming Zhou,Changlin Tian,Shilong Yang,Ren Lai +19 more
TL;DR: The study indicates that centipedes’ venom has evolved to simultaneously disrupt cardiovascular, respiratory, muscular, and nervous systems by targeting the broadly distributed KCNQ channels, thus providing a therapeutic strategy for centipede envenomation.
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Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel.
TL;DR: A pain-inducing peptide (BmP01) has been identified and characterized from the venoms of scorpion and this is the first report about a scorpion toxin that produces pain by targeting TRPV1, to the authors' knowledge.
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Molecular basis for heat desensitization of TRPV1 ion channels
Lei Luo,Yunfei Wang,Yunfei Wang,Bowen Li,Lizhen Xu,Peter Muiruri Kamau,Peter Muiruri Kamau,Jie Zheng,Fan Yang,Shilong Yang,Ren Lai +10 more
TL;DR: The authors find that the platypus form of TRPV1 does not desensitize, identify the mechanism underlying this property, and show that knock-in of this form of the receptor in mice leads to deficits in heat sensitivity.
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Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel.
Lizhen Xu,Yalan Han,Yalan Han,Xiaoying Chen,Aerziguli Aierken,Han Wen,Wenjun Zheng,Hongkun Wang,Xiancui Lu,Xiancui Lu,Zhenye Zhao,Cheng Ma,Ping Liang,Wei Yang,Shilong Yang,Fan Yang +15 more
TL;DR: This study docked menthol to TRPM8 and systematically validate their menthol binding models with thermodynamic mutant cycle analysis in functional tests, and shed light onTRPM8 activation by menthol at the atomic level.