Shin-ichi Tsunoda

TL;DR: In this paper, the authors showed that nanoparticles with diameters of 70 nm and 35 nm can cause pregnancy complications when injected intravenously into pregnant mice, and that these detrimental effects are linked to structural and functional abnormalities in the placenta on the maternal side, and are abolished when the surfaces of the silica nanoparticles are modified with carboxyl and amine groups.

TL;DR: In this article, the relationship between particle size and the in vitro effect of amorphous nanosilica (nSP) was evaluated using human keratinocyte cells (HaCaT) and showed that exposure to nSP of 70 nm diameter induced an elevated level of reactive oxygen species (ROS), leading to DNA damage.

TL;DR: Taken together, nano-size materials may be hepatotoxic, and these findings will be useful for future development in nanotechnology-based drug delivery system.

TL;DR: The 3.0 angstrom resolution structure of the TNF-TNFR2 complex was solved and provided insight into the molecular recognition of TNF by TNFR2, which may contribute to the design of therapeutics for autoimmune diseases.

TL;DR: Assessment of biopharmaceutical properties of various nonionic water-soluble polymers as polymeric drug carriers suggested that PVP is the most suitable polymeric modifier for prolonging the circulation lifetime of a drug and localizing the conjugated drug in blood.