Tomoaki Yoshikawa

TL;DR: In this paper, the authors showed that nanoparticles with diameters of 70 nm and 35 nm can cause pregnancy complications when injected intravenously into pregnant mice, and that these detrimental effects are linked to structural and functional abnormalities in the placenta on the maternal side, and are abolished when the surfaces of the silica nanoparticles are modified with carboxyl and amine groups.

TL;DR: In this article, the relationship between particle size and the in vitro effect of amorphous nanosilica (nSP) was evaluated using human keratinocyte cells (HaCaT) and showed that exposure to nSP of 70 nm diameter induced an elevated level of reactive oxygen species (ROS), leading to DNA damage.

TL;DR: Comparison of inflammatory responses of various types of CNTs found that peritoneal CNT administration of long and thick MWCNTs increased the total cell number in abdominal lavage fluid in mice, suggesting DNA damage and severe inflammatory effects.

TL;DR: The results suggested that the well-dispersed amorphous nanosilica of particle size 70 nm (nSP70) penetrated the skin barrier and caused systemic exposure in mouse, and induced mutagenic activity in vitro, indicated that further studies of relation between physicochemical properties and biological responses are needed for the development and the safer form of NMs.

TL;DR: It is demonstrated that IL-1 family cytokines are potential mucosal vaccine adjuvants and can induce Ag-specific immune responses for protection against pathogens like influenza virus.