Norio Itoh

TL;DR: In this paper, the authors showed that nanoparticles with diameters of 70 nm and 35 nm can cause pregnancy complications when injected intravenously into pregnant mice, and that these detrimental effects are linked to structural and functional abnormalities in the placenta on the maternal side, and are abolished when the surfaces of the silica nanoparticles are modified with carboxyl and amine groups.

TL;DR: Recently, the use of a dioxetane-disulfide derivative as a chemiluminescent probe in place of DTNB led to an improved sensitivity of the AChE assay with acetylthiocholine (ASCh) by a factor of ten.

TL;DR: In this article, the relationship between particle size and the in vitro effect of amorphous nanosilica (nSP) was evaluated using human keratinocyte cells (HaCaT) and showed that exposure to nSP of 70 nm diameter induced an elevated level of reactive oxygen species (ROS), leading to DNA damage.

TL;DR: Fluorometric detection of O2-* is performed based on desulfonylation of 3 to the corresponding fluoresceins 4 through nucleophilic substitution with satisfactory sensitivity, and effects of glutathione, cytochrome P450 reductase /NADPH, and diaphorase/NADH are relatively small on the fluorescing process.

TL;DR: Comparison of inflammatory responses of various types of CNTs found that peritoneal CNT administration of long and thick MWCNTs increased the total cell number in abdominal lavage fluid in mice, suggesting DNA damage and severe inflammatory effects.