Shinya Tsukiji

TL;DR: Two types of photo-controllable translational activation systems that are compatible with modRNAs are developed that will expand the application of mammalian synthetic biology research.

TL;DR: This article showed that VEGF-dependent release of thromboxane A2 (TXA2) triggers Ca2+ transients in tumor cells, culminating in PGE2 secretion and subsequent immune evasion in the early stages of tumorigenesis.

TL;DR: A new enzymatic protein ligation tool, sortase, has recently emerged from Gram-positive bacteria as mentioned in this paper, and its applications in protein engineering, which include the introduction of unnatural molecules into proteins, protein immobilization, protein conjugation, protein cyclization, as a self-cleavable tag for protein expression, protein-PNA hybrids, neoglycoconjugates, and cell-surface protein labeling.

TL;DR: It is shown that it is feasible to rapidly and efficiently activate an endogenous signaling pathway by placing a synthetic ligand at a specific location within a cell.

TL;DR: Ruthenium-tris(bipyridine)-appended heme is successfully reconstituted with apo-cytochrome b============ 562============ (Cyt-b======676 562¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ as mentioned in this paper, which can be switched by visible light irradiation.