Shiran Shapira

TL;DR: It is reported that eosinophils are recruited into developing tumors during induction of inflammation-induced colorectal cancer and in mice with the Apcmin/+ genotype, which develop spontaneous intestinal adenomas, and it is demonstrated that the TME supported prolonged eos inophil survival independent of IL5, an eosInophils survival cytokine.

TL;DR: Currently known molecular biomarkers used for the personalized treatment of colorectal cancer are reviewed to identify reliable biomarkers which will guide clinicians in decision making, while matching suitable therapeutic regimens.

TL;DR: The possible molecular mechanism for terpinen-4-ol activity involves induction of cell-death rendering this compound as a potential anti-cancer drug alone and in combination in the treatment of numerous malignancies.

TL;DR: Anti-CD24 SWA11 mAb can deliver a PE exotoxin derivative to CRC cells and cause them to undergo apoptosis, without toxicity to normal tissues.

TL;DR: The APC p.I1307K gene variant is an important risk factor for colorectal neoplasia in average risk Ashkenazi Jews, and carriers in this group should be considered for screening colonoscopy at the age of 40, to be repeated every 5 years, similar to recommendations in individuals with family history of coloreCTal cancer.