M
Mickey S. Urdea
Researcher at Chiron Corporation
Publications - 129
Citations - 13944
Mickey S. Urdea is an academic researcher from Chiron Corporation. The author has contributed to research in topics: BDNA test & Hepatitis C virus. The author has an hindex of 54, co-authored 129 publications receiving 13855 citations. Previous affiliations of Mickey S. Urdea include Washington State University & University Medical Center New Orleans.
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Journal ArticleDOI
Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region
Peter Simmonds,Edward C. Holmes,Tai-An Cha,Shiu-Wan Chan,F. McOmish,Irvine Bruce,Beall Eileen,P L Yap,Janice A. Kolberg,Mickey S. Urdea +9 more
TL;DR: A new nomenclature for HCV variants is proposed in this communication that reflects the two-tiered nature of sequence differences between different viral isolates and describes criteria that would enable new variants to be assigned within the classification as they are discovered.
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Significance of serum hepatitis C virus RNA levels in chronic hepatitis C
Joseph Lau,Gary L. Davis,J Kniffen,Ke-Ping Qian,Mickey S. Urdea,C. S. Chan,Paul Neuwald,Judith C. Wilber,Masashi Mizokami +8 more
TL;DR: Findings indicate that mode of acquisition is an important determinant of HCV viraemia and that patients with low HCVviraemia levels are more likely to respond to interferon in a sustained fashion.
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cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines
Christer Betsholtz,Ann Johnsson,Carl-Henrik Heldin,Bengt Westermark,Peter Lind,Mickey S. Urdea,Roger L. Eddy,Thomas B. Shows,Karen L. Philpott,Andrew L. Mellor,Timothy J. Knott,James F. Scott +11 more
TL;DR: The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7, showing extensive homology to the PDGF B-chain precursor.
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Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae
Anthony J. Brake,James P Merryweather,Doris Coit,Ulrike Heberlein,Frank R. Masiarz,Guy T. Mullenbach,Mickey S. Urdea,Pablo Valenzuela,Philip J. Barr +8 more
TL;DR: Saccharomyces cerevisiae cells were transformed with plasmids containing hybrid genes in which the sequence encoding mature human epidermal growth factor was joined to sequences encoding the leader region (preprosegment) of the precursor of the yeast mating pheromone alpha-factor.
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Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor
James C. Scott,Mark Selby,Mickey S. Urdea,Margarita Quiroga,Graeme I. Bell,William J. Rutter +5 more
TL;DR: The nucleotide sequence of a submaxillary cDNA encoding the mouse NGF precursor (preproNGF) is reported, in contrast to previous suppositions, where the NGF moiety is situated near the carboxy-terminus of the polyprotein precursor.