S
Shogo Ehata
Researcher at University of Tokyo
Publications - 47
Citations - 2599
Shogo Ehata is an academic researcher from University of Tokyo. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 28, co-authored 44 publications receiving 2104 citations. Previous affiliations of Shogo Ehata include Japanese Foundation for Cancer Research.
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Journal ArticleDOI
Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway.
Yoko Katsuno,Yoko Katsuno,Aki Hanyu,Hiroaki Kanda,Yuichi Ishikawa,Futoshi Akiyama,T Iwase,Etsuro Ogata,Shogo Ehata,Kohei Miyazono,Kohei Miyazono,Takeshi Imamura +11 more
TL;DR: It is suggested that BMPs as well as TGF-β promote invasion and bone metastasis of breast cancer.
Journal ArticleDOI
TGF-β regulates isoform switching of FGF receptors and epithelial–mesenchymal transition
Takuya Shirakihara,Kana Horiguchi,Keiji Miyazawa,Shogo Ehata,Tatsuhiro Shibata,Ikuo Morita,Kohei Miyazono,Masao Saitoh,Masao Saitoh,Masao Saitoh +9 more
TL;DR: It is demonstrated that transforming growth factor (TGF)‐β induced EMT and that long‐term exposure to TGF‐β elicited the epithelial–myofibroblastic transition (EMyoT) by inactivating the MEK‐Erk pathway.
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Whole-Body Profiling of Cancer Metastasis with Single-Cell Resolution
Shimpei I. Kubota,Kei Takahashi,Jun Nishida,Yasuyuki Morishita,Shogo Ehata,Kazuki Tainaka,Kohei Miyazono,Hiroki R. Ueda,Hiroki R. Ueda +8 more
TL;DR: CUBIC-cancer analysis suggests that the epithelial-mesenchymal transition promotes not only extravasation but also cell survival at metastatic sites, and suggests that a scalable analytical pipeline with these three modalities may contribute to addressing currently incurable metastatic diseases.
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Effect of Smad7 Expression on Metastasis of Mouse Mammary Carcinoma JygMC(A) Cells
Haruhito Azuma,Shogo Ehata,Hideyo Miyazaki,Tetsuro Watabe,Osamu Maruyama,Takeshi Imamura,Takeshi Sakamoto,Satoshi Kiyama,Yuko Kiyama,Takanobu Ubai,Teruo Inamoto,Shiro Takahara,Yuko Itoh,Yoshinori Otsuki,Yoji Katsuoka,Kohei Miyazono,Shigeo Horie +16 more
TL;DR: Systemic expression of Smad7 may be a novel strategy for the prevention of metastasis of advanced cancers by regulating cell-cell adhesion and decreasing in the migratory and invasive abilities of the JygMC(A) cells.
Journal ArticleDOI
Intracellular and extracellular TGF-β signaling in cancer: some recent topics.
TL;DR: This review will focus on recent findings regarding epithelial-mesenchymal transition (EMT) induced by TGF-β, in relation to crosstalk with some other signaling pathways, and the roles of T GF-β in lung and pancreatic cancers, in which TDF-β has been shown to be involved in cancer progression.