T
Takeshi Imamura
Researcher at Ehime University
Publications - 187
Citations - 20968
Takeshi Imamura is an academic researcher from Ehime University. The author has contributed to research in topics: SMAD & Bone morphogenetic protein. The author has an hindex of 71, co-authored 172 publications receiving 19517 citations. Previous affiliations of Takeshi Imamura include Japanese Foundation for Cancer Research & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression
Asako Sakaue-Sawano,Hiroshi Kurokawa,Toshifumi Morimura,Aki Hanyu,Hiroshi Hama,Hatsuki Osawa,Saori Kashiwagi,Kiyoko Fukami,Takaki Miyata,Hiroyuki Miyoshi,Takeshi Imamura,Masaharu Ogawa,Hisao Masai,Atsushi Miyawaki +13 more
TL;DR: Time-lapse imaging is performed to explore the spatiotemporal patterns of cell-cycle dynamics during the epithelial-mesenchymal transition of cultured cells, the migration and differentiation of neural progenitors in brain slices, and the development of tumors across blood vessels in live mice.
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TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.
Atsuhito Nakao,Takeshi Imamura,Takeshi Imamura,Serhiy Souchelnytskyi,Masahiro Kawabata,Akira Ishisaki,Eiichi Oeda,Kiyoshi Tamaki,Jun-ichi Hanai,Carl-Henrik Heldin,Kohei Miyazono,Peter ten Dijke +11 more
TL;DR: It is shown that Smad2 and Smad3 interacted with the kinase‐deficient TGF‐β type I receptor (TβR)‐I after it was phosphorylated by TβR‐II kinase, which suggests that T GF‐β induces heteromeric complexes of Smad 2, 3 and 4, and their concomitant translocation to the nucleus, which is required for efficient TGF-β signal transduction.
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Smad6 inhibits signalling by the TGF-Beta superfamily
Takeshi Imamura,Masao Takase,Ayako Nishihara,Eiichi Oeda,Jun-ichi Hanai,Masahiro Kawabata,Kohei Miyazono +6 more
TL;DR: The isolation of Smad6 in the mouse indicates that signals of the TGF-β superfamily are regulated both positively and negatively by members of the SMAD family.
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Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis
S. Paul Oh,Tsugio Seki,Kendrick A. Goss,Takeshi Imamura,Youngsuk Yi,Patricia K. Donahoe,Li Li,Kohei Miyazono,Peter ten Dijke,Seong-Jin Kim,En Li +10 more
TL;DR: The results suggest that the balance between the ALK1 and ALK5 signaling pathways in endothelial cells plays a crucial role in determining vascular endothelial properties during angiogenesis.
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BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk
TL;DR: Bone morphogenetic proteins, members of the transforming growth factor-beta (TGF-beta) superfamily, bind to two different serine/threonine kinase receptors, and mediate their signals through Smad-dependent and Smad -independent pathways.