S
Shohei Hori
Researcher at University of Tokyo
Publications - 84
Citations - 26244
Shohei Hori is an academic researcher from University of Tokyo. The author has contributed to research in topics: FOXP3 & Immune system. The author has an hindex of 45, co-authored 78 publications receiving 23639 citations. Previous affiliations of Shohei Hori include Instituto Gulbenkian de Ciência & Kyoto University.
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Journal ArticleDOI
Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis.
Junko Nishio,Minato Baba,Koji Atarashi,Takeshi Tanoue,Hideo Negishi,Hideyuki Yanai,Sonoko Habu,Shohei Hori,Kenya Honda,Tadatsugu Taniguchi +9 more
TL;DR: It is shown that the development of spontaneous colitis, a T-helper type 17 cell-mediated inflammation driven by gut microbiota, is accompanied by a paucity of peripherally derived regulatory T cells and hyperactivation of migratory dendritic cells, revealing a new facet of the TCR repertoire in which Tregs require a diverse TCR repitoire for intestinal homeostasis.
Journal ArticleDOI
c-Rel: A pioneer in directing regulatory T-cell lineage commitment?
TL;DR: It is shown that a member of the NF‐κB family transcription factors, c‐Rel, is required for thymic differentiation of Foxp3+ Treg and may act as a pioneer transcription factor in initiatingFoxp3 transcription in Treg precursors in the thymus.
Book ChapterDOI
Thymic generation and selection of CD25+CD4+ regulatory T cells: Implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance
Shimon Sakaguchi,Shohei Hori,Yoshinori Fukui,Takehiko Sasazuki,Noriko Sakaguchi,Takeshi Takahashi +5 more
TL;DR: This recent study with transgenic mice has revealed that a particular self-peptide/MHC ligand in the thymus can positively select a broad repertoire of functionally mature CD25+CD4+ regulatory T cells as well as naive T cells, ensuring dominant control of self-reactive T cells.
Journal ArticleDOI
Enhanced efficacy of regulatory T cell transfer against increasing resistance, by elevated Foxp3 expression induced in arthritic murine hosts
TL;DR: Resistance to Foxp3-transduced T cells proceeded as CIA progressed, suggesting that late-stage aggressive arthritis is more resistant to regulatory T cell transfer.
Journal ArticleDOI
Rethinking the molecular definition of regulatory T cells.
TL;DR: Emerging evidence suggests that the Treg lineage may be determined by a higher‐order regulatory process that ensures stable and high levels Foxp3 expression.