T
Takeshi Takahashi
Researcher at Central Institute for Experimental Animals
Publications - 80
Citations - 16213
Takeshi Takahashi is an academic researcher from Central Institute for Experimental Animals. The author has contributed to research in topics: Immune system & IL-2 receptor. The author has an hindex of 34, co-authored 75 publications receiving 15342 citations. Previous affiliations of Takeshi Takahashi include Tohoku University & Kyoto University.
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Journal ArticleDOI
Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
Takeshi Takahashi,Tomoyuki Tagami,Sayuri Yamazaki,Toshimitsu Uede,Jun Shimizu,Noriko Sakaguchi,Tak W. Mak,Shimon Sakaguchi +7 more
TL;DR: Interference with this role of CTLA-4 suffices to elicit autoimmune disease in otherwise normal animals, presumably through affecting CD25+CD4+ T cell–mediated control of self-reactive T cells.
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Stimulation of CD25 + CD4 + regulatory T cells through GITR breaks immunological self-tolerance
TL;DR: GITR plays a key role in dominant immunological self-tolerance maintained by CD25+CD4+ regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease.
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Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.
Takeshi Takahashi,Yuhshi Kuniyasu,Masaaki Toda,Noriko Sakaguchi,Misako Itoh,Makoto Iwata,Jun Shimizu,Shimon Sakaguchi +7 more
TL;DR: The results taken together indicate that one aspect of immunologic self-tolerance is maintained by this unique CD25+CD4+ naturally anergic/suppressive T cell population and its functional abnormality directly leads to the development of autoimmune disease.
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Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance.
Shimon Sakaguchi,Noriko Sakaguchi,Jun Shimizu,Sayuri Yamazaki,Toshiko Sakihama,Misako Itoh,Yuhshi Kuniyasu,Takashi Nomura,Masaaki Toda,Takeshi Takahashi +9 more
TL;DR: There is accumulating evidence that T‐cell‐mediated dominant control of self‐reactive T‐cells contributes to the maintenance of immunologic self‐tolerance and its alteration can cause autoimmune disease.
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Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease
Shimon Sakaguchi,Masahiro Ono,Ruka Setoguchi,Haruhiko Yagi,Shohei Hori,Zoltan Fehervari,Jun Shimizu,Takeshi Takahashi,Takashi Nomura +8 more
TL;DR: Elucidation of the molecular and cellular basis of this Treg‐mediated active maintenance of self‐tolerance will facilitate both the understanding of the pathogenetic mechanism of autoimmune disease and the development of novel methods of autoimmunity prevention and treatment via enhancing and re‐establishing T Reg‐mediated dominant control over self‐reactive T cells.