H
Hideyuki Yanai
Researcher at University of Tokyo
Publications - 66
Citations - 13861
Hideyuki Yanai is an academic researcher from University of Tokyo. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 36, co-authored 61 publications receiving 12637 citations.
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Journal ArticleDOI
IRF-7 is the master regulator of type-I interferon-dependent immune responses
Kenya Honda,Hideyuki Yanai,Hideo Negishi,Masataka Asagiri,Mitsuharu Sato,Tatsuaki Mizutani,Naoya Shimada,Yusuke Ohba,Yusuke Ohba,Akinori Takaoka,Nobuaki Yoshida,Tadatsugu Taniguchi +11 more
TL;DR: It is shown that mice deficient in the Irf7 gene are more vulnerable than Myd88-/- mice to viral infection, and this correlates with a marked decrease in serum IFN levels, indicating the importance of the IRF-7-dependent induction of systemic IFN responses for innate antiviral immunity.
Journal ArticleDOI
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
Akinori Takaoka,ZhiChao Wang,Myoung Kwon Choi,Hideyuki Yanai,Hideo Negishi,Tatsuma Ban,Yan Lu,Makoto Miyagishi,Tatsuhiko Kodama,Kenya Honda,Yusuke Ohba,Tadatsugu Taniguchi +11 more
TL;DR: The artificial expression of otherwise IFN-inducible DAI (DLM-1/ZBP1) in mouse fibroblasts selectively enhances the DNA-mediated induction of type I IFN and other genes involved in innate immunity, and may offer new insight into the signalling mechanisms underlying DNA-associated antimicrobial immunity and autoimmune disorders.
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The IRF Family Transcription Factors in Immunity and Oncogenesis
TL;DR: The role of several IRF family members in the regulation of the cell cycle and apoptosis has important implications for understanding susceptibility to and progression of several cancers.
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Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
Akinori Takaoka,Hideyuki Yanai,Seiji Kondo,Gordon S. Duncan,Hideo Negishi,Tatsuaki Mizutani,Shin Ichi Kano,Kenya Honda,Yusuke Ohba,Tak W. Mak,Tadatsugu Taniguchi +10 more
TL;DR: The transcription factor IRF-5 is identified as a new, principal downstream regulator of the TLR–MyD88 signalling pathway and a potential target of therapeutic intervention to control harmful immune responses.
Journal ArticleDOI
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction.
Kenya Honda,Yusuke Ohba,Yusuke Ohba,Hideyuki Yanai,Hideo Negishi,Tatsuaki Mizutani,Akinori Takaoka,Choji Taya,Tadatsugu Taniguchi +8 more
TL;DR: Insight is offered into the regulation of TLR9 signalling in space, potentially suggesting a new avenue for therapeutic intervention in response toTLR9 activation.