Shohreh Issazadeh-Navikas

TL;DR: In this paper, the function of interferons (IFNs) in regulating neuronal mitochondrial homeostasis is unknown, but it has been shown that neuronal IFN-β is indispensable for mitochondrial metabolism, sustaining ATP levels and preventing excessive ROS by controlling mitochondrial fission.

TL;DR: It is demonstrated that CD1d KO mice, as compared with Wt littermates, have more pronounced infiltration of mononuclear cells in the skin and peritoneal cavity and increased production of interferon‐γ after DNCB sensitisation and challenge, which suggests an important regulatory and protective role ofCD1d‐dependent NKT cells in CHS in this model, at least in part via regulation of IL‐10 producing Bregs.

TL;DR: In the light of an ongoing debate as to whether psilocybin is a safe treatment for depression and other mental illnesses, it is reassuring that the data suggest that any effects on gene expression are very modest.

TL;DR: It is discovered that intranasal treatment of mice with CpG-ODN results in mild synovitis particularly in IFN-β-/- mice, and this finding is a warning for possible negative effects of C pG- ODN vaccination.

TL;DR: Interestingly, TSC skin recipients displayed a reduced T and B cell response to CII and were also protected from arthritis, and development of arthritis was not accompanied by graft rejection, showing that these immune‐mediated inflammatory responses involve different mechanisms.