J
Jens Vilstrup Johansen
Researcher at University of Copenhagen
Publications - 52
Citations - 5553
Jens Vilstrup Johansen is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Gene & Demethylase. The author has an hindex of 26, co-authored 47 publications receiving 4749 citations.
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Journal ArticleDOI
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
Kristine Williams,Jesper Christensen,Marianne Terndrup Pedersen,Jens Vilstrup Johansen,Paul A. C. Cloos,Juri Rappsilber,Kristian Helin +6 more
TL;DR: It is proposed that TET1 fine-tunes transcription, opposes aberrant DNA methylation at CpG-rich sequences and thereby contributes to the regulation ofDNA methylation fidelity.
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JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
Diego Pasini,Paul A. C. Cloos,Julian Walfridsson,Linda Olsson,John Paul Bukowski,Jens Vilstrup Johansen,Mads Bak,Niels Tommerup,Juri Rappsilber,Kristian Helin +9 more
TL;DR: It is demonstrated that JARID2 is essential for the binding of PcG proteins to target genes and, consistent with this, for the proper differentiation of embryonic stem cells and normal development.
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EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas
Faizaan Mohammad,Simon Weissmann,Benjamin Leblanc,Deo Prakash Pandey,Jonas W. Højfeldt,Itys Comet,Chunqin Zheng,Jens Vilstrup Johansen,Nicolas Rapin,Bo T. Porse,Andrey Tvardovskiy,Andrey Tvardovskiy,Ole N. Jensen,Ole N. Jensen,Nagore G. Olaciregui,Cinzia Lavarino,Mariona Suñol,Carmen de Torres,Jaume Mora,Angel M. Carcaboso,Kristian Helin +20 more
TL;DR: Results show that residual PRC2 activity is required for the proliferation of H3K27M-expressing DIPGs, and that inhibition of EZH2 is a potential therapeutic strategy for the treatment of these tumors.
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Gene Silencing Triggers Polycomb Repressive Complex 2 Recruitment to CpG Islands Genome Wide
TL;DR: The results show that it is the transcriptional state that governs PRC2 binding, and it is proposed that it binds by default to nontranscribed CGI genes to maintain their silenced state and to protect cell identity.
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Fbxl10/Kdm2b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H2A Ubiquitylation
TL;DR: It is shown that Fbxl10 interacts with Ring1B and Nspc1, forming a noncanonical PRC1 that is required for H2AK119ub1 in mouse ESCs and has a key role in regulating Ring1 B recruitment to its target genes and H2 AK119 ubiquitylation in ESCs.