S
Shreekant Deshpande
Researcher at Central Drug Research Institute
Publications - 12
Citations - 201
Shreekant Deshpande is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Quantitative structure–activity relationship & Receptor tyrosine kinase. The author has an hindex of 7, co-authored 12 publications receiving 181 citations. Previous affiliations of Shreekant Deshpande include Academy of Scientific and Innovative Research & Council of Scientific and Industrial Research.
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Synthesis and biological evaluation of 3,4,6-triaryl-2-pyranones as a potential new class of anti-breast cancer agents.
Ravi Shankar,Bandana Chakravarti,Uma S. Singh,Mohd. Imran Ansari,Shreekant Deshpande,Shailendra Kumar Dhar Dwivedi,Hemant K. Bid,Rituraj Konwar,Geetika Kharkwal,Vishal Chandra,Anila Dwivedi,Kanchan Hajela +11 more
TL;DR: A series of 3,4,6-triaryl-2-pyranones, new class of anti-breast cancer agents, have been synthesized as a structural variants of cyclic triphenylethylenes by replacing the fused benzene ring with pendant phenyl ring to mimic the phenolic A ring of estradiol.
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Cypermethrin induces astrocyte apoptosis by the disruption of the autocrine/paracrine mode of epidermal growth factor receptor signaling.
Shailendra Kumar Maurya,Asit Rai,Nagendra Kumar Rai,Shreekant Deshpande,Rajeev Jain,Mohana Krishna Reddy Mudiam,Yenamandra S. Prabhakar,Sanghamitra Bandyopadhyay +7 more
TL;DR: It is demonstrated that cypermethrin induces astrocyte apoptosis by disrupting the autocrine/paracrine mode of HB-EGF-EGFR signaling at two levels, irreversible loss of basal EGFR and downregulation of HB -EGF.
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Synthesis and biological evaluation of 2,3,4-triarylbenzopyran derivatives as SERM and therapeutic agent for breast cancer.
Shailesh Kumar,Shreekant Deshpande,Vishal Chandra,Shakti Kitchlu,Anila Dwivedi,Vadithe Lakshma Nayak,Rituraj Konwar,Yenamandra S. Prabhakar,Devi Prasad Sahu +8 more
TL;DR: A novel class of 2,3,4-triarylbenzopyrans synthesized and evaluated for their selective estrogen receptor modulation activity and as a therapeutic agent for breast cancer showed low IC(50) value, suggesting these compounds probably act through ER independent mechanism.
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Is Feature Selection Essential for ANN Modeling
Mohammad Taghi Goodarzi,Mohammad Taghi Goodarzi,Shreekant Deshpande,Vanangamudi Murugesan,Seturam B. Katti,Yenamandra S. Prabhakar +5 more
TL;DR: Prior feature selection is not essential for ANN and it is a desirable option for meaningful outputs in terms of the rationale behind the inputs, as investigated with a variety of objectively selected and arbitrarily chosen variables from chemical databases.
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Topological descriptors in modelling antimalarial activity: N(1)-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine as prototype.
TL;DR: The QSAR of antimalarial activity of two distinct series of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl) piperazine analogues are investigated with DRAGON descriptors in order to rationalize their activity.