K
Kanchan Hajela
Researcher at Central Drug Research Institute
Publications - 44
Citations - 711
Kanchan Hajela is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Apoptosis & Cell growth. The author has an hindex of 15, co-authored 44 publications receiving 599 citations. Previous affiliations of Kanchan Hajela include Academy of Scientific and Innovative Research.
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Synthesis and biological activities of some new dibenzopyranones and dibenzopyrans: search for potential oestrogen receptor agonists and antagonists
TL;DR: Some new tricyclic molecules bridged between the active molecules of 3,4-Diaryl chroman and 2,3-diaryl benzopyrans have been synthesised to search for newer oestrogen agonists or antagonists.
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Synthesis and biological evaluation of 3,4,6-triaryl-2-pyranones as a potential new class of anti-breast cancer agents.
Ravi Shankar,Bandana Chakravarti,Uma S. Singh,Mohd. Imran Ansari,Shreekant Deshpande,Shailendra Kumar Dhar Dwivedi,Hemant K. Bid,Rituraj Konwar,Geetika Kharkwal,Vishal Chandra,Anila Dwivedi,Kanchan Hajela +11 more
TL;DR: A series of 3,4,6-triaryl-2-pyranones, new class of anti-breast cancer agents, have been synthesized as a structural variants of cyclic triphenylethylenes by replacing the fused benzene ring with pendant phenyl ring to mimic the phenolic A ring of estradiol.
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Design and synthesis of ERα/ERβ selective coumarin and chromene derivatives as potential anti-breast cancer and anti-osteoporotic agents
M. Kamil Hussain,M. Imran Ansari,N.S. Yadav,Puneet Gupta,Amit K. Gupta,Ruchi Saxena,Iram Fatima,Murli Manohar,Priyanka Kushwaha,Vikram Khedgikar,Jyoti Gautam,Ruchir Kant,P. R. Maulik,Ritu Trivedi,Anil Kumar Dwivedi,K. Ravi Kumar,Anil K. Saxena,Kanchan Hajela +17 more
TL;DR: Several new coumarin and chromene prototype derivatives have been synthesised and evaluated for their ERα and ERβ selective activity, and the surprise finding of the series are the novel prototype III chromenes 45 & 46, with aroyl substitution at the 6th position.
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NAD+-dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis: novel structure-function relationship and identification of a specific inhibitor.
Sandeep Kumar Srivastava,Divya Dube,Vandana Kukshal,Ashok K. Jha,Kanchan Hajela,Ravishankar Ramachandran +5 more
TL;DR: In silico ligand‐docking studies suggest that the exquisite specificity of the inhibitor arises on account of its mimicking the interactions of NAD+ with MtuLigA, and an analysis of conserved water in the binding site of the enzyme suggests strategies for synthesis of improved inhibitors with better specificity and potency.
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Tandem C-2 functionalization-intramolecular azide-alkyne 1,3-dipolar cycloaddition reaction: a convenient route to highly diversified 9H-benzo[b]pyrrolo[1,2-g][1,2,3]triazolo[1,5-d][1,4]diazepines.
TL;DR: The reaction shows high substrate tolerance and provides a library of fused heterocycles that may lead to novel biologically active compounds or drug lead molecules.