S
Shridhar P. Damle
Researcher at Rockefeller University
Publications - 17
Citations - 312
Shridhar P. Damle is an academic researcher from Rockefeller University. The author has contributed to research in topics: Glycosaminoglycan & Keratan sulfate. The author has an hindex of 8, co-authored 17 publications receiving 309 citations.
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Journal ArticleDOI
Sera from patients with poststreptococcal glomerulonephritis contain antibodies to glomerular heparan sulfate proteoglycan.
Howard Fillit,Shridhar P. Damle,John D. Gregory,Cathy Volin,Theo Poon-King,John B. Zabriskie +5 more
TL;DR: Antibodies, found in human sera from patients with poststreptococcal glomerulonephritis, against proteoglycans (PG) derived from bovine and human glomeruli were investigated and demonstrated that heparan sulfate was a major antigenic determinant.
Journal Article
Biochemical analyses of proteoglycans in rabbit corneal scars.
TL;DR: Cornea adjacent to the healing wound synthesized PGs measurably different fro those in scar and normal cornea, and the authors conclude that corneal macromolecules synthesized in vitro was remarkably similar to that in vivo.
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Monoclonal antibodies to heparan sulfate proteoglycan: development and application to the study of normal tissue and pathologic human kidney biopsies.
Eva Kemeny,Howard Fillit,Shridhar P. Damle,Ram Mahabir,Nicholas A. Kefalides,John D. Gregory,Tatiana T. Antonovych,Sharda G. Sabnis,John B. Zabriskie +8 more
TL;DR: Indirect immunofluorescence showed that the mAbs stained renal basement membranes (BMs) and BMs in other organs of normal bovine and human tissues in patterns typical of HSPG.
Journal ArticleDOI
Examination of corneal proteoglycans and glycosaminoglycans by rotary shadowing and electron microscopy.
John E. Scott,Christine Cummings,Helmut Greiling,Helmut W. Stuhlsatz,John D. Gregory,Shridhar P. Damle +5 more
TL;DR: The results on corneal DS PG confirm and extend the hypothesis that PGs specifically associated with collagen fibrils are tadpole shaped, and it is unsafe to assume the absence of GAGs, based on these techniques, and quantitative measurements of length may be subject to error.
Journal ArticleDOI
Monoclonal antibodies to proteokeratan sulfate of rabbit corneal stroma.
TL;DR: None of the antibodies reacted immunohistochemically with macular dystrophic corneas, confirming the finding of others that the defect lies in the keratan sulfate portion of the proteoglycans.