S
Shrivats Mohan Iyer
Researcher at Stanford University
Publications - 17
Citations - 1384
Shrivats Mohan Iyer is an academic researcher from Stanford University. The author has contributed to research in topics: Optogenetics & Motor neuron. The author has an hindex of 11, co-authored 17 publications receiving 1148 citations. Previous affiliations of Shrivats Mohan Iyer include Johns Hopkins University School of Medicine & Johns Hopkins University.
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Journal ArticleDOI
Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice
Kate L. Montgomery,Alexander J. Yeh,John S. Ho,Vivien Tsao,Shrivats Mohan Iyer,Logan Grosenick,Emily A. Ferenczi,Yuji Tanabe,Karl Deisseroth,Scott L. Delp,Ada S. Y. Poon +10 more
TL;DR: It is shown how three adaptations of the implant allow for untethered optogenetic control throughout the nervous system (brain, spinal cord and peripheral nerve endings) of behaving mice.
Journal ArticleDOI
Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice.
Shrivats Mohan Iyer,Kate L. Montgomery,Chris Towne,Soo Yeun Lee,Charu Ramakrishnan,Karl Deisseroth,Scott L. Delp +6 more
TL;DR: An optogenetic strategy is used to bidirectionally control nociceptors of nontransgenic mice to enable rapid drug screening and testing of newly engineered opsins and have utility in basic and translational pain research.
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Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity
Andre Berndt,Soo Yeun Lee,Jonas Wietek,Charu Ramakrishnan,Elizabeth E. Steinberg,Asim J. Rashid,Hoseok Kim,Sungmo Park,Adam Santoro,Paul W. Frankland,Shrivats Mohan Iyer,Sally Pak,Sofie Ährlund-Richter,Scott L. Delp,Robert C. Malenka,Sheena A. Josselyn,Marie Carlén,Peter Hegemann,Karl Deisseroth +18 more
TL;DR: The validation and further development of the channelrhodopsin pore model is reported via crystal structure-guided engineering of next-generation light-activated chloride channels and a bistable variant with net photocurrents increased more than 15-fold under physiological conditions.
Journal ArticleDOI
Optogenetic Control of Targeted Peripheral Axons in Freely Moving Animals
Chris Towne,Kate L. Montgomery,Shrivats Mohan Iyer,Karl Deisseroth,Karl Deisseroth,Scott L. Delp +5 more
TL;DR: Methods to deliver opsins and light to targeted peripheral neurons and robust optogenetic modulation of motor neuron activity in freely moving, non-transgenic mammals are reported here.
Journal ArticleDOI
Beyond the brain: Optogenetic control in the spinal cord and peripheral nervous system
Kate L. Montgomery,Shrivats Mohan Iyer,Amelia J. Christensen,Karl Deisseroth,Karl Deisseroth,Scott L. Delp +5 more
TL;DR: Challenges in using optogenetics to study the mammalian spinal cord and peripheral nervous system are discussed, common features that unite the work done thus far are synthesized, and a route forward for the successful application of optogenetic research to translational research beyond the brain is described.