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Shuai Wu
Researcher at Hong Kong Polytechnic University
Publications - 6
Citations - 443
Shuai Wu is an academic researcher from Hong Kong Polytechnic University. The author has contributed to research in topics: Autophagy & UVRAG. The author has an hindex of 4, co-authored 5 publications receiving 292 citations.
Papers
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Journal ArticleDOI
Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates
Junghyun Lim,M. Lenard Lachenmayer,Shuai Wu,Wenchao Liu,Mondira Kundu,Rong Wang,Masaaki Komatsu,Young J. Oh,Yanxiang Zhao,Zhenyu Yue +9 more
TL;DR: Proteotoxic stress imposed by the proteasome inhibition or expression of polyglutamine expanded huntingtin induces p62 phosphorylation at its ubiquitin-association (UBA) domain that regulates its binding to ubiquitinated proteins, suggesting a potential novel drug target for the treatment of proteinopathies including Huntington's disease.
Journal ArticleDOI
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway
Zhiqiang Deng,Junghyun Lim,Junghyun Lim,Qian Wang,Kerry Purtell,Shuai Wu,Gloria M. Palomo,Haiyan Tan,Giovanni Manfredi,Yanxiang Zhao,Junmin Peng,Bo Hu,Shi Chen,Zhenyu Yue +13 more
TL;DR: The results reveal a mechanism whereby pathogenic SQSTM1 mutants inhibit selective autophagy and disrupt NFE2L2 anti-oxidative stress response underlying the neurotoxicity in ALS-FTLD.
Journal ArticleDOI
Importance of TFEB acetylation in control of its transcriptional activity and lysosomal function in response to histone deacetylase inhibitors.
Jianbin Zhang,Jigang Wang,Zhihong Zhou,Jung Eun Park,Liming Wang,Shuai Wu,Xin Sun,Liqin Lu,Tianru Wang,Qingsong Lin,Siu Kwan Sze,Dongsheng Huang,Han-Ming Shen +12 more
TL;DR: TFEB acetylation was functionally implicated in SAHA-mediated autophagy and cell death in cancer cells, and was demonstrated to be a novel form of posttranslational modifications in TFEB that plays an important role in determining its transcriptional activity, lysosomal function and Autophagy incancer cells.
Journal ArticleDOI
Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking.
Shuai Wu,Yunjiao He,Yunjiao He,Xianxiu Qiu,Wenchao Yang,Wenchao Yang,Wenchao Liu,Xiaohua Li,Yan Li,Han-Ming Shen,Renxiao Wang,Zhenyu Yue,Yanxiang Zhao +12 more
TL;DR: The designed peptides can target the Beclin 1 coiled-coil domain, promote Atg14L– and UVRAG–BeClin 1 interaction, induce autophagy, and significantly enhance endolysosomal degradation of the EGF receptor.
Patent
Hydrocarbon-stapled polypeptides for enhancement of endosome-lysosomal degradation
TL;DR: In this paper, a Beclin 1-UVRAG complex structure was revealed, which reveals a tightly packed coiled coil assembly with BeclIN 1 and UVRAG residues complementing each other to form a stable dimeric complex.