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Shuhei Hige
Researcher at Hokkaido University
Publications - 71
Citations - 4382
Shuhei Hige is an academic researcher from Hokkaido University. The author has contributed to research in topics: Hepatitis B virus & Pegylated interferon. The author has an hindex of 24, co-authored 68 publications receiving 4184 citations.
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Journal ArticleDOI
Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.
Yasuhito Tanaka,Nao Nishida,Masaya Sugiyama,Masayuki Kurosaki,Kentaro Matsuura,Naoya Sakamoto,Mina Nakagawa,Masaaki Korenaga,Keisuke Hino,Shuhei Hige,Yoshito Ito,Eiji Mita,Eiji Tanaka,Satoshi Mochida,Yoshikazu Murawaki,Masao Honda,Akito Sakai,Yoichi Hiasa,Shuhei Nishiguchi,Asako Koike,Isao Sakaida,Masatoshi Imamura,Kiyoaki Ito,Koji Yano,Naohiko Masaki,Fuminaka Sugauchi,Namiki Izumi,Katsushi Tokunaga,Masashi Mizokami +28 more
TL;DR: A genome-wide association study to null virological response (NVR) in the treatment of patients with hepatitis C virus (HCV) genotype 1 within a Japanese population is reported.
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A serum "sweet-doughnut" protein facilitates fibrosis evaluation and therapy assessment in patients with viral hepatitis.
Atsushi Kuno,Yuzuru Ikehara,Yasuhito Tanaka,Kiyoaki Ito,Atsushi Matsuda,Satoru Sekiya,Shuhei Hige,Michiie Sakamoto,Masayoshi Kage,Masashi Mizokami,Hisashi Narimatsu +10 more
TL;DR: A glycan-based immunoassay, FastLec-Hepa, is the only assay currently available for clinically beneficial therapy evaluation through quantitation of disease severity and is sufficiently sensitive and quantitative to evaluate the effects of PEG-interferon-α/ribavirin therapy in a short post-therapeutic interval.
Journal ArticleDOI
Influence of genotypes and precore mutations on fulminant or chronic outcome of acute hepatitis B virus infection.
Atsushi Ozasa,Yasuhito Tanaka,Etsuro Orito,Masaya Sugiyama,Jong-Hon Kang,Shuhei Hige,Tomoyuki Kuramitsu,Kazuyuki Suzuki,Eiji Tanaka,Shunichi Okada,Hajime Tokita,Yasuhiro Asahina,Kazuaki Inoue,Shinichi Kakumu,Takeshi Okanoue,Yoshikazu Murawaki,Keisuke Hino,Morikazu Onji,Hiroshi Yatsuhashi,Hiroshi Sakugawa,Yuzo Miyakawa,Ryuzo Ueda,Masashi Mizokami +22 more
TL;DR: The outcome of acute hepatitis B virus (HBV) infection is variable, influenced by host and viral factors, and fulminant hepatitis was frequent and associated with Bj and lack of HBeAg as well as high replication due to precore mutation in patients with acute HBV infection.
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Amelioration of dextran sulfate sodium–induced colitis by anti-macrophage migration inhibitory factor antibody in mice ☆ ☆☆
Tatsuya Ohkawara,Jun Nishihira,Hiroshi Takeda,Shuhei Hige,Mototsugu Kato,Toshiro Sugiyama,Toshihiko Iwanaga,Hideki Nakamura,Yuka Mizue,Masahiro Asaka +9 more
TL;DR: It is concluded that anti-MIF antibodies reduce the severity of experimental colitis and limit the up-regulation of Th1-type cytokines.
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Progressive disappearance of anti-hepatitis B surface antigen antibody and reverse seroconversion after allogeneic hematopoietic stem cell transplantation in patients with previous hepatitis B virus infection.
Masahiro Onozawa,Satoshi Hashino,Koh Izumiyama,Kaoru Kahata,Makoto Chuma,Akio Mori,Takeshi Kondo,Nobuyasu Toyoshima,Shuichi Ota,Sumiko Kobayashi,Shuhei Hige,Tomomi Toubai,Junji Tanaka,Masahiro Imamura,Masahiro Asaka +14 more
TL;DR: RS is a late-onset complication with high frequency that can be predicted by careful monitoring of progressive decrease in anti-HBs titer, observed in 14 recipients with pretransplant anti-hepatitis B surface antigen antibody (anti- HBs).