M
Masaaki Korenaga
Researcher at Kawasaki Medical School
Publications - 97
Citations - 5479
Masaaki Korenaga is an academic researcher from Kawasaki Medical School. The author has contributed to research in topics: Hepatitis C virus & Hepatitis C. The author has an hindex of 29, co-authored 88 publications receiving 5125 citations. Previous affiliations of Masaaki Korenaga include Yamaguchi University.
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Journal ArticleDOI
Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.
Yasuhito Tanaka,Nao Nishida,Masaya Sugiyama,Masayuki Kurosaki,Kentaro Matsuura,Naoya Sakamoto,Mina Nakagawa,Masaaki Korenaga,Keisuke Hino,Shuhei Hige,Yoshito Ito,Eiji Mita,Eiji Tanaka,Satoshi Mochida,Yoshikazu Murawaki,Masao Honda,Akito Sakai,Yoichi Hiasa,Shuhei Nishiguchi,Asako Koike,Isao Sakaida,Masatoshi Imamura,Kiyoaki Ito,Koji Yano,Naohiko Masaki,Fuminaka Sugauchi,Namiki Izumi,Katsushi Tokunaga,Masashi Mizokami +28 more
TL;DR: A genome-wide association study to null virological response (NVR) in the treatment of patients with hepatitis C virus (HCV) genotype 1 within a Japanese population is reported.
Journal ArticleDOI
Hepatitis C Virus Core Protein Inhibits Mitochondrial Electron Transport and Increases Reactive Oxygen Species (ROS) Production
Masaaki Korenaga,Ting Wang,Yanchun Li,Lori A. Showalter,Tehsheng Chan,Jiaren Sun,Steven A. Weinman +6 more
TL;DR: Results suggest that interaction of core protein with mitochondria and subsequent oxidation of the glutathione pool and complex I inhibition may be an important cause of the oxidative stress seen in chronic hepatitis C.
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Ledipasvir and sofosbuvir fixed-dose combination with and without ribavirin for 12 weeks in treatment-naive and previously treated Japanese patients with genotype 1 hepatitis C: an open-label, randomised, phase 3 trial.
Masashi Mizokami,Osamu Yokosuka,Tetsuo Takehara,Naoya Sakamoto,Masaaki Korenaga,Hitoshi Mochizuki,Kunio Nakane,Hirayuki Enomoto,Fusao Ikeda,Mikio Yanase,Hidenori Toyoda,Takuya Genda,Takeji Umemura,Hiroshi Yatsuhashi,Tatsuya Ide,Nobuo Toda,Kazushige Nirei,Yoshiyuki Ueno,Yoichi Nishigaki,Juan Betular,Bing Gao,Akinobu Ishizaki,Masa Omote,Hongmei Mo,Kim Garrison,Phillip S. Pang,Steven J. Knox,William T. Symonds,John G. McHutchison,Namiki Izumi,Masao Omata +30 more
TL;DR: The efficacy and safety of an all-oral, fixed-dose combination of the hepatitis C virus NS5A inhibitor ledipasvir and the NS5B nucleotide polymerase inhibitor sofosbuvir with and without ribavirin for 12 weeks in treatment-naive and previously treated Japanese patients with chronic genotype 1 hepatitis Cirus infection is assessed.
Journal ArticleDOI
Hepatitis C Virus–Induced Reactive Oxygen Species Raise Hepatic Iron Level in Mice by Reducing Hepcidin Transcription
Sohji Nishina,Keisuke Hino,Masaaki Korenaga,Chiara Vecchi,Antonello Pietrangelo,Yoichi Mizukami,Takakazu Furutani,Aya Sakai,Michiari Okuda,Isao Hidaka,Kiwamu Okita,Isao Sakaida +11 more
TL;DR: HCV-induced reactive oxygen species may down-regulate hepcidin transcription through inhibition of C/EBPalpha DNA binding activity by C/EBP homology protein, which in turn leads to increased duodenal iron transport and macrophage iron release, causing hepatic iron accumulation.
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Elevated serum levels of Wisteria floribunda agglutinin-positive human Mac-2 binding protein predict the development of hepatocellular carcinoma in hepatitis C patients
Kazumi Yamasaki,Masakuni Tateyama,Seigo Abiru,Atsumasa Komori,Shinya Nagaoka,Akira Saeki,Satoru Hashimoto,Ryu Sasaki,Shigemune Bekki,Yuki Kugiyama,Yuri Miyazoe,Atsushi Kuno,Masaaki Korenaga,Akira Togayachi,Makoto Ocho,Masashi Mizokami,Hisashi Narimatsu,Hiroshi Yatsuhashi +17 more
TL;DR: WFA+‐M2BP can be applied as a useful surrogate marker for the risk of HCC development, in addition to liver biopsy.