S
Shurong Hou
Researcher at University of Kentucky
Publications - 34
Citations - 955
Shurong Hou is an academic researcher from University of Kentucky. The author has contributed to research in topics: Butyrylcholinesterase & Medicine. The author has an hindex of 17, co-authored 29 publications receiving 802 citations. Previous affiliations of Shurong Hou include Scripps Research Institute & Chinese Academy of Sciences.
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Journal ArticleDOI
Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening.
Shurong Hou,Hervé Tiriac,BanuPriya Sridharan,Louis Scampavia,Franck Madoux,Franck Madoux,Jan Seldin,Glauco R. Souza,Donald Watson,David A. Tuveson,Timothy P. Spicer +10 more
TL;DR: An HTS-compatible method that enables the consistent production of organoids in standard flat-bottom 384- and 1536-well plates by combining the use of a cell-repellent surface with a bioprinting technology incorporating magnetic force is described.
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Design, Preparation, and Characterization of High-Activity Mutants of Human Butyrylcholinesterase Specific for Detoxification of Cocaine
Liu Xue,Mei-Chuan Ko,Min Tong,Wen-Chao Yang,Shurong Hou,Lei Fang,Junjun Liu,Fang Zheng,James H. Woods,Hsin-Hsiung Tai,Chang-Guo Zhan +10 more
TL;DR: Two representative BChE mutants have been confirmed to be potent in actual protection of mice from acute toxicity of a lethal dose of cocaine (180 mg/kg) and future direction for further improving the efficacy of the enzyme in the cocaine overdose treatment is revealed.
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A highly efficient cocaine-detoxifying enzyme obtained by computational design
TL;DR: The catalytic efficiency of E30-6 for cocaine hydrolysis is comparable to that of the most efficient known naturally-occurring hydrolytic enzyme, acetylcholinesterase, the catalytic activity of which approaches the diffusion limit.
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Determination of dopamine in the presence of ascorbic acid using poly(3,5-dihydroxy benzoic acid) film modified electrode.
TL;DR: This work provides a simple and easy approach to selective detection of DA in the presence of AA and the interference of ascorbic acid (AA) was effectively eliminated.
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Long-acting cocaine hydrolase for addiction therapy
TL;DR: A novel CocH form, a catalytic antibody analog, which is a fragment crystallizable (Fc)-fused CocH dimer (CocH-Fc) constructed by using CocH to replace the Fab region of human IgG1, which has a high catalytic efficiency against cocaine but also has a considerably longer biological half-life.