S
Shurong Huang
Researcher at United States Department of Agriculture
Publications - 8
Citations - 1124
Shurong Huang is an academic researcher from United States Department of Agriculture. The author has contributed to research in topics: Proinflammatory cytokine & Docosahexaenoic acid. The author has an hindex of 7, co-authored 8 publications receiving 940 citations. Previous affiliations of Shurong Huang include University of California, Davis.
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Journal ArticleDOI
Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways
Shurong Huang,Jennifer M. Rutkowsky,Ryan G. Snodgrass,Kikumi D. Ono-Moore,Dina A. Schneider,John W. Newman,John W. Newman,Sean H. Adams,Sean H. Adams,Daniel H. Hwang,Daniel H. Hwang +10 more
TL;DR: These results and additional studies with the LPS sequester polymixin B and in MyD88−/− macrophages indicated that SFA-induced activation of TLR2 or TLR4 is a fatty acid-specific effect, but not due to contaminants in BSA or fatty acid preparations.
Journal ArticleDOI
Acylcarnitines activate proinflammatory signaling pathways
Jennifer M. Rutkowsky,Trina A. Knotts,Kikumi D. Ono-Moore,Colin S. McCoin,Shurong Huang,Dina A. Schneider,Shamsher Singh,Sean H. Adams,Daniel H. Hwang +8 more
TL;DR: Results point to potential involvement of PRRs as acylcarnitine promoted IL-8 secretion from human epithelial cells (HCT-116) lacking Toll-like receptors (TLR)2 and -4, and did not activate reporter constructs in TLR overexpression cell models.
Journal ArticleDOI
Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; Modulation by dietary fatty acids
Ryan G. Snodgrass,Shurong Huang,Il-Whan Choi,John C. Rutledge,Daniel H. Hwang,Daniel H. Hwang +5 more
TL;DR: Mechanistic insight is revealed about how palmitic acid activates TLR2, upregulates NALP3 expression, and induces inflammasome-mediated IL-1β production in human monocytes, which can trigger enhanced inflammation in peripheral tissues, and suggest that these processes are dynamically modulated by the types of dietary fat the authors consume.
Journal ArticleDOI
Differential modulation of Nods signaling pathways by fatty acids in human colonic epithelial HCT116 cells.
Ling Zhao,Myung Ja Kwon,Shurong Huang,Joo Y. Lee,Koichi Fukase,Naohiro Inohara,Daniel H. Hwang +6 more
TL;DR: The differential modulation of NF-κB activation and interleukin-8 expression in colonic epithelial cells HCT116 is shown by saturated and unsaturated fatty acids mediated through Nods proteins, suggesting that Nods may be involved in inducing sterile inflammation.