R
Ryan G. Snodgrass
Researcher at Goethe University Frankfurt
Publications - 26
Citations - 1208
Ryan G. Snodgrass is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Proinflammatory cytokine & Inflammation. The author has an hindex of 12, co-authored 22 publications receiving 926 citations. Previous affiliations of Ryan G. Snodgrass include United States Department of Agriculture & University of California, Davis.
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Journal ArticleDOI
Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways
Shurong Huang,Jennifer M. Rutkowsky,Ryan G. Snodgrass,Kikumi D. Ono-Moore,Dina A. Schneider,John W. Newman,John W. Newman,Sean H. Adams,Sean H. Adams,Daniel H. Hwang,Daniel H. Hwang +10 more
TL;DR: These results and additional studies with the LPS sequester polymixin B and in MyD88−/− macrophages indicated that SFA-induced activation of TLR2 or TLR4 is a fatty acid-specific effect, but not due to contaminants in BSA or fatty acid preparations.
Journal ArticleDOI
Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; Modulation by dietary fatty acids
Ryan G. Snodgrass,Shurong Huang,Il-Whan Choi,John C. Rutledge,Daniel H. Hwang,Daniel H. Hwang +5 more
TL;DR: Mechanistic insight is revealed about how palmitic acid activates TLR2, upregulates NALP3 expression, and induces inflammasome-mediated IL-1β production in human monocytes, which can trigger enhanced inflammation in peripheral tissues, and suggest that these processes are dynamically modulated by the types of dietary fat the authors consume.
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Regulation and Functions of 15-Lipoxygenases in Human Macrophages.
Ryan G. Snodgrass,Bernhard Brüne +1 more
TL;DR: This review aims to summarize the current knowledge on the regulation and functions of ALOX15 and ALOx15B in human macrophages.
Journal ArticleDOI
Hypoxia Potentiates Palmitate-induced Pro-inflammatory Activation of Primary Human Macrophages
Ryan G. Snodgrass,Marcel Boß,Ekaterina Zezina,Andreas Weigert,Nathalie Dehne,Ingrid Fleming,Bernhard Brüne,Dmitry Namgaladze +7 more
TL;DR: The results reveal that the coexistence of hypoxia along with free fatty acids exacerbates macrophage-mediated inflammation.
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Mitomycin C inhibits ribosomal RNA: a novel cytotoxic mechanism for bioreductive drugs.
TL;DR: The interaction of MMC with ribosomal RNA and subsequent inhibition of protein translation is consistent with mechanisms proposed for other natural compounds.