Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways
Shurong Huang,Jennifer M. Rutkowsky,Ryan G. Snodgrass,Kikumi D. Ono-Moore,Dina A. Schneider,John W. Newman,John W. Newman,Sean H. Adams,Sean H. Adams,Daniel H. Hwang,Daniel H. Hwang +10 more
Reads0
Chats0
TLDR
These results and additional studies with the LPS sequester polymixin B and in MyD88−/− macrophages indicated that SFA-induced activation of TLR2 or TLR4 is a fatty acid-specific effect, but not due to contaminants in BSA or fatty acid preparations.About:
This article is published in Journal of Lipid Research.The article was published on 2012-09-01 and is currently open access. It has received 492 citations till now. The article focuses on the topics: Fatty acid & Docosahexaenoic acid.read more
Citations
More filters
Journal ArticleDOI
Inflammaging: a new immune–metabolic viewpoint for age-related diseases
TL;DR: It is argued that chronic diseases are not only the result of ageing and inflammaging; these diseases also accelerate the ageing process and can be considered a manifestation of accelerated ageing, and the use of new biomarkers capable of assessing biological versus chronological age in metabolic diseases is proposed.
Journal ArticleDOI
Inflammation, metaflammation and immunometabolic disorders
TL;DR: Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental to cellular and organismal survival and are paramount to health.
Journal ArticleDOI
Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling
Robert Caesar,Valentina Tremaroli,Petia Kovatcheva-Datchary,Patrice D. Cani,Fredrik Bäckhed,Fredrik Bäckhed +5 more
TL;DR: It is shown that mice fed lard for 11 weeks have increased Toll-like receptor activation and WAT inflammation and reduced insulin sensitivity compared with mice fed fish oil and that phenotypic differences between the dietary groups can be partly attributed to differences in microbiota composition.
Journal ArticleDOI
Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health
TL;DR: Current knowledge of how macronutrient metabolism by the gut microbiome influences human health is summarized and knowledge gaps that could contribute to the understanding of overall human wellness will be identified.
Journal ArticleDOI
Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling
TL;DR: The current state of the knowledge on the involvement of rafts in TLR4 signaling is summarized, with an emphasis on how the raft proteins regulate the TLR 4 signaling pathways.
References
More filters
Journal ArticleDOI
TLR4 links innate immunity and fatty acid–induced insulin resistance
TL;DR: It is suggested that TLR4 is a molecular link among nutrition, lipids, and inflammation and that the innate immune system participates in the regulation of energy balance and insulin resistance in response to changes in the nutritional environment.
Journal ArticleDOI
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
Veit Hornung,Franz Bauernfeind,Annett Halle,Eivind O. Samstad,Eivind O. Samstad,Hajime Kono,Kenneth L. Rock,Katherine A. Fitzgerald,Eicke Latz,Eicke Latz +9 more
TL;DR: It is demonstrated that silica and aluminum salt crystals activated inflammasomes formed by the cytoplasmic receptor NALP3, which senses lysosomal damage as an endogenous 'danger' signal.
Journal ArticleDOI
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
Adrian Ozinsky,David M. Underhill,Jason D. Fontenot,Adeline M. Hajjar,Kelly D. Smith,Christopher B. Wilson,Lea Schroeder,Alan Aderem +7 more
TL;DR: The data suggest that TLRs sample the contents of the phagosome independent of the nature of the contents, and can establish a combinatorial repertoire to discriminate among the large number of pathogen-associated molecular patterns found in nature.
Journal ArticleDOI
The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex
TL;DR: The TLR4–MD-2–LPS structure illustrates the remarkable versatility of the ligand recognition mechanisms employed by the TLR family, which is essential for defence against diverse microbial infection.
Journal ArticleDOI
Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex
TL;DR: It is reported here that macrophages of C3H/HeJ mice, carrying a mutant Toll-like-receptor (Tlr) 4 are nonresponsive to hsp60, and this is the first report of a putative endogenous ligand of the Tlr4 complex.
Related Papers (5)
Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani,Jacques Amar,Miguel A. Iglesias,Marjorie Poggi,Claude Knauf,Delphine Bastelica,Audrey M. Neyrinck,Francesca Fava,Kieran Tuohy,Chantal Chabo,Aurélie Waget,Evelyne Delmée,Béatrice Cousin,Thierry Sulpice,Bernard Chamontin,Jean Ferrières,Jean-François Tanti,Glenn R. Gibson,Louis Casteilla,Nathalie M. Delzenne,Marie-Christine Alessi,Rémy Burcelin +21 more