S
Shuwen Lei
Researcher at Boston University
Publications - 7
Citations - 176
Shuwen Lei is an academic researcher from Boston University. The author has contributed to research in topics: Stress granule & Integrated stress response. The author has an hindex of 4, co-authored 7 publications receiving 59 citations.
Papers
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Journal ArticleDOI
TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau.
Peter E.A. Ash,Shuwen Lei,Jenifer Shattuck,Samantha Boudeau,Yari Carlomagno,Maria Medalla,Bryce L Mashimo,Guillermo Socorro,Louloua F A Al-Mohanna,Lulu Jiang,Muhammet M Öztürk,Mark Knobel,Pavel Ivanov,Leonard Petrucelli,Susanne Wegmann,Nicholas M. Kanaan,Benjamin Wolozin +16 more
TL;DR: In this paper, the interaction of tau with RNA and the RNA binding protein TIA1 is shown to drive phase separation at physiological concentrations, without the requirement for artificial crowding agents such as polyethylene glycol (PEG).
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Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy
Lulu Jiang,Weiwei Lin,Cheng Zhang,Peter E.A. Ash,Mamta Verma,Julian Kwan,Emily van Vliet,Zhuo Yang,Anna Lourdes Cruz,Samantha Boudeau,Brandon F. Maziuk,Shuwen Lei,Jaehyup Song,Victor E. Alvarez,Stacy Hovde,Jose F. Abisambra,Min Hao Kuo,Nicholas M. Kanaan,Melissa E. Murray,John F. Crary,Jian Zhao,Ji-Xin Cheng,Leonard Petrucelli,Hu Li,Andrew Emili,Benjamin Wolozin +25 more
TL;DR: In this paper, the authors used Cry2-based optogenetics to induce tau oligomers (oTau-c), which elicits tau phosphorylation, aggregation, and reduced protein synthesis.
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Heavy Metal Neurotoxicants Induce ALS-Linked TDP-43 Pathology.
Peter E.A. Ash,Uma Dhawan,Uma Dhawan,Samantha Boudeau,Shuwen Lei,Yari Carlomagno,Mark Knobel,Louloua F A Al Mohanna,Steven R. Boomhower,M. Christopher Newland,David H. Sherr,Benjamin Wolozin +11 more
TL;DR: Novel evidence of a direct mechanistic link between heavy metals, which are a commonly cited environmental risk of ALS, and molecular changes in TDP-43, the primary pathological protein accumulating in ALS is provided.
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Strain isolation: A simple mechanism for understanding and detecting structures of zero Poisson's ratio
TL;DR: In this paper, a strain-isolation mechanism is proposed to explain the ZPR behavior of the reversed semi-re-entrant (RSRE) honeycomb, and the model of the 3D RSRE structure showing ZPR behaviors in three orthogonal planes.
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The influence of moisture content on the interfacial properties of natural palm fiber-matrix composite
TL;DR: In this paper, the influence of moisture content on the interfacial properties of natural palm was investigated by using an oval fiber pull-out model and scanning electron microscopy was used to examine the fiber interfacial morphology.