Sierra McDonald

TL;DR: The transcription factor TOX is a central regulator of the transcriptional and epigenetic development of exhausted T cells in mice, and robust expression of TOX results in commitment to Tex cells by translating persistent stimulation into a distinct Tex cell transcriptionaland epigenetic developmental program.

TL;DR: It is demonstrated that cytotoxic 5FU impairs muscle damage repair and remodeling concomitant with a loss of immune cells that persists beyond the cessation of treatment.

TL;DR: This mini-review will discuss the interactions between the immune system and the gut microbiome in the case of UC and suggest nonpharmacological and behavioral strategies aimed at restoring a proper microbial-immune relationship.

TL;DR: It is demonstrated that obese mice are not protected against cancer/chemotherapy-induced cachexia and other toxicities, but rather show evidence of increased susceptibility to 5FU-induced cytotoxicity even when dosed for relative lean mass.

TL;DR: In this paper , the authors investigated surgical wounding's impact on tumor progression and lung metastasis in a murine model of triple negative breast cancer (TNBC), which is likely mediated, at least in part by an increase in macrophages.