R
Ryan P. Staupe
Researcher at University of Pennsylvania
Publications - 11
Citations - 2514
Ryan P. Staupe is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Immune system & Cytotoxic T cell. The author has an hindex of 6, co-authored 6 publications receiving 1559 citations.
Papers
More filters
Journal ArticleDOI
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response
Alexander C. Huang,Michael A. Postow,Michael A. Postow,Robert J. Orlowski,Rosemarie Mick,Bertram Bengsch,Sasikanth Manne,Wei Xu,Shannon Harmon,Josephine R. Giles,Brandon Wenz,Matthew Adamow,Deborah Kuk,Katherine S. Panageas,Cristina Carrera,Cristina Carrera,Phillip Wong,Felix Quagliarello,Bradley Wubbenhorst,Kurt D'Andrea,Kristen E. Pauken,Ramin S. Herati,Ryan P. Staupe,Jason M. Schenkel,Suzanne McGettigan,Shawn Kothari,Sangeeth M. George,Robert H. Vonderheide,Ravi K. Amaravadi,Giorgos C. Karakousis,Lynn M. Schuchter,Xiaowei Xu,Katherine L. Nathanson,Jedd D. Wolchok,Tara C. Gangadhar,E. John Wherry +35 more
TL;DR: Blood profiling of peripheral blood from patients with stage IV melanoma before and after treatment with the PD-1-targeting antibody pembrolizumab is used to identify pharmacodynamic changes in circulating exhausted-phenotype CD8 T cells (Tex cells) and identify a clinically accessible potential on-treatment predictor of response to PD- 1 blockade.
Journal ArticleDOI
TOX transcriptionally and epigenetically programs CD8 + T cell exhaustion
Omar Khan,Josephine R. Giles,Sierra McDonald,Sasikanth Manne,Shin Foong Ngiow,Kunal P. Patel,Michael T. Werner,Alexander C. Huang,Katherine A. Alexander,Jennifer E. Wu,John Attanasio,Patrick Yan,Sangeeth M. George,Bertram Bengsch,Bertram Bengsch,Ryan P. Staupe,Greg Donahue,Wei Xu,Ravi K. Amaravadi,Xiaowei Xu,Giorgos C. Karakousis,Tara C. Mitchell,Lynn M. Schuchter,Jonathan Kaye,Shelley L. Berger,E. John Wherry +25 more
TL;DR: The transcription factor TOX is a central regulator of the transcriptional and epigenetic development of exhausted T cells in mice, and robust expression of TOX results in commitment to Tex cells by translating persistent stimulation into a distinct Tex cell transcriptionaland epigenetic developmental program.
Journal ArticleDOI
TCF-1-Centered Transcriptional Network Drives an Effector Versus Exhausted CD8 T Cell-Fate Decision
Zeyu Chen,Zhicheng Ji,Shin Foong Ngiow,Sasikanth Manne,Zhangying Cai,Alexander C. Huang,John L. Johnson,Ryan P. Staupe,Bertram Bengsch,Caiyue Xu,Sixiang Yu,Makoto Kurachi,Ramin S. Herati,Laura A. Vella,Laura A. Vella,Amy E. Baxter,Jennifer E. Wu,Omar Khan,Jean Christophe Beltra,Josephine R. Giles,Erietta Stelekati,Laura M. McLane,Chi Wai Lau,Xiaolu Yang,Shelley L. Berger,Golnaz Vahedi,Hongkai Ji,E. John Wherry +27 more
TL;DR: A role for TCF-1 in early-fate-bifurcation-driving Tex precursor cells is defined and PD-1 is identified as a protector of this early TCf-1 subset.
Journal ArticleDOI
Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection.
Burton E. Barnett,Ryan P. Staupe,Pamela M. Odorizzi,Olesya Palko,Vesselin T. Tomov,Alison E. Mahan,Bronwyn M. Gunn,Diana Chen,Michael A. Paley,Galit Alter,Steven L. Reiner,Georg M. Lauer,John R. Teijaro,E. John Wherry +13 more
TL;DR: It is demonstrated that B cell–specific loss of T-bet prevents control of persisting viral infection, supporting a model in which T-Bet is a universal controller of antiviral immunity across multiple immune lineages.
Journal ArticleDOI
Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells.
Laura M. McLane,Shin Foong Ngiow,Zeyu Chen,John Attanasio,Sasikanth Manne,Gordon Ruthel,Jennifer E. Wu,Ryan P. Staupe,Wei Xu,Ravi K. Amaravadi,Xiaowei Xu,Giorgos C. Karakousis,Tara C. Mitchell,Lynn M. Schuchter,Alexander C. Huang,Bruce D. Freedman,Michael R. Betts,E. John Wherry +17 more
TL;DR: In this paper, the subcellular localization of T-bet and Eomes dictate their regulatory activity in exhausted T-cells (TEXs) in preclinical cancer models and in human tumors.