Sigalit Boura-Halfon

TL;DR: A range of conditions that activate IRS kinases to phosphorylate IRS proteins on "hot spot" domains are reviewed and their implications on insulin signaling, insulin resistance and type 2 diabetes, an emerging epidemic of the 21st century are outlined.

TL;DR: A previously unappreciated homeostatic role for macrophages in the control of tissue innervation is reported, which might contribute to the phenotype by repulsion of sympathetic axons expressing the transmembrane semaphorin Sema6A.

TL;DR: A side-by-side comparison of classical cell-sorting-based transcriptome sequencing and the ‘RiboTag’ method, which avoids cell retrieval from tissue context and yields translatome sequencing information is reported, indicating method-based biases, reveals observer effects and establishes RiboTag-based transl atome profiling as a valuable complement to standard sorting-based profiling strategies.

TL;DR: It is concluded that the sphingolipid acyl chain composition of liver regulates insulin signaling by modifying insulin receptor translocation into membrane microdomains.

TL;DR: The mutated seven Ser sites located proximal to the phosphotyrosine binding domain of insulin receptor substrate 1 (IRS-1) are mutated into Ala and suggest that S408 and additional Ser sites among the seven mutated Ser sites are targets for IRS-1 kinases that play a key negative regulatory role in IRS- 1 function and insulin action.