S
Simon Yona
Researcher at Hebrew University of Jerusalem
Publications - 85
Citations - 12785
Simon Yona is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Inflammation & Mononuclear phagocyte system. The author has an hindex of 40, co-authored 80 publications receiving 10624 citations. Previous affiliations of Simon Yona include University of Oxford & Hadassah Medical Center.
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Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Simon Yona,Ki-Wook Kim,Yochai Wolf,Alexander Mildner,Diana Varol,Michal Breker,Dalit Strauss-Ayali,Sergey Viukov,Martin Guilliams,Alexander V. Misharin,David A. Hume,Harris Perlman,Bernard Malissen,Elazar Zelzer,Steffen Jung +14 more
TL;DR: A fate-mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression is reported, establishing that short-lived Ly6C(+) monocytes constitute obligatory steady-state precursors of blood-resident Ly 6C(-) cells and that the abundance of Ly6 C(+) blood monocytes dynamically controls the circulation lifespan of their progeny.
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis (vol 38, pg 79, 2013)
Simon Yona,K-W Kim,Yochai Wolf,Alexander Mildner,Diana Varol,Michal Breker,Dalit Strauss-Ayali,Sergey Viukov,Martin Guilliams,A Misharin,David A. Hume,Harris Perlman,Bernard Malissen,Elazar Zelzer,S Jung +14 more
TL;DR: In this paper, a fate-mapping study of the macrophage compartment is presented, taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression.
Journal ArticleDOI
Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny
Martin Guilliams,Florent Ginhoux,Claudia Jakubzick,Shalin H. Naik,Nobuyuki Onai,Barbara U. Schraml,Elodie Segura,Roxane Tussiwand,Simon Yona +8 more
TL;DR: This Opinion article suggests that the mononuclear phagocyte system can be classified primarily by their ontogeny and secondarily by their location, function and phenotype, which permits a more robust classification during both steady-state and inflammatory conditions.
Journal ArticleDOI
The fate and lifespan of human monocyte subsets in steady state and systemic inflammation.
Amit Patel,Yan Zhang,James N. Fullerton,Lies Boelen,Anthony Rongvaux,Alexander A. Maini,Bigley,Richard A. Flavell,Richard A. Flavell,Derek W. Gilroy,Becca Asquith,Derek C. Macallan,Derek C. Macallan,Simon Yona +13 more
TL;DR: It is demonstrated that classical monocytes emerge first from marrow, after a postmitotic interval of 1.6 d, and circulate for a day, which is consistent with a model of sequential transition.
Journal ArticleDOI
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
Tobias Goldmann,Peter Wieghofer,Philippe F. Müller,Yochai Wolf,Diana Varol,Simon Yona,Stefanie M. Brendecke,Katrin Kierdorf,Ori Staszewski,Moumita Datta,Tom Luedde,Mathias Heikenwalder,Steffen Jung,Marco Prinz +13 more
TL;DR: A mouse experimental system that specifically targets microglia found TAK1 to be pivotal in CNS autoimmunity, and it is presented as a tool for future investigations of microglial function in the CNS.