S
Sigrid S. Skånland
Researcher at Goethe University Frankfurt
Publications - 20
Citations - 818
Sigrid S. Skånland is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 2 publications receiving 703 citations.
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Journal ArticleDOI
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.
Fumiyo Ikeda,Yonathan Lissanu Deribe,Sigrid S. Skånland,Benjamin Stieglitz,Caroline Grabbe,Caroline Grabbe,Mirita Franz-Wachtel,Sjoerd J L van Wijk,Panchali Goswami,Vanja Nagy,Janoš Terzić,Fuminori Tokunaga,Ariadne Androulidaki,Tomoko Nakagawa,Manolis Pasparakis,Kazuhiro Iwai,John P. Sundberg,Liliana Schaefer,Katrin Rittinger,Boris Macek,Ivan Dikic,Ivan Dikic +21 more
TL;DR: It is reported that SHARPIN functions as a novel component of the linear ubiquitin chain assembly complex (LUBAC) and that the absence of SHARPin causes dysregulation of NF-κB and apoptotic signalling pathways, explaining the severe phenotypes displayed by chronic proliferative dermatitis (cpdm) in SHARPIn-deficient mice.
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Spatial organization of transmembrane receptor signalling
TL;DR: Lipid microdomains have a function in tuning the activity of many transmembrane receptors by positively or negatively affecting receptor clustering and signal transduction.
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PI3K inhibitors in chronic lymphocytic leukemia: where do we go from here?
TL;DR: It is of interest to optimize the administration of currently approved PI3K inhibitors and to develop next-generation agents to improve tolerability, so that this class of agents will be considered an effective and safe treatment option when needed.
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Approach to a patient with “double refractory” chronic lymphocytic leukemia: “Double, double toil and trouble” (Shakespeare)
TL;DR: This article attempts to define the “double refractory” patient as resistant to both Bruton's tyrosine kinase inhibitors (BTKi) and venetoclax for which prognosis is poor and there remains no standard of care.
Journal ArticleDOI
Functional testing of relapsed chronic lymphocytic leukemia guides precision medicine and maps response and resistance mechanisms. An index case
Sigrid S. Skånland,Marit Inngjerdingen,Henrik Bendiksen,Jamie Piers York,Signe Spetalen,Ludvig A. Munthe,Geir E. Tjønnfjord +6 more
TL;DR: In this article , the authors propose a method to solve the problem of "not available" data: https://www.youtube.com/watch/watch?feature=youtu.