C
Caroline Grabbe
Researcher at Umeå University
Publications - 23
Citations - 2331
Caroline Grabbe is an academic researcher from Umeå University. The author has contributed to research in topics: Drosophila melanogaster & Drosophila Protein. The author has an hindex of 17, co-authored 23 publications receiving 2135 citations. Previous affiliations of Caroline Grabbe include Goethe University Frankfurt.
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Journal ArticleDOI
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.
Fumiyo Ikeda,Yonathan Lissanu Deribe,Sigrid S. Skånland,Benjamin Stieglitz,Caroline Grabbe,Caroline Grabbe,Mirita Franz-Wachtel,Sjoerd J L van Wijk,Panchali Goswami,Vanja Nagy,Janoš Terzić,Fuminori Tokunaga,Ariadne Androulidaki,Tomoko Nakagawa,Manolis Pasparakis,Kazuhiro Iwai,John P. Sundberg,Liliana Schaefer,Katrin Rittinger,Boris Macek,Ivan Dikic,Ivan Dikic +21 more
TL;DR: It is reported that SHARPIN functions as a novel component of the linear ubiquitin chain assembly complex (LUBAC) and that the absence of SHARPin causes dysregulation of NF-κB and apoptotic signalling pathways, explaining the severe phenotypes displayed by chronic proliferative dermatitis (cpdm) in SHARPIn-deficient mice.
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Anaplastic lymphoma kinase: signalling in development and disease
TL;DR: The role of ALK in development and disease is addressed, implications for the future are discussed and many chromosomal rearrangements leading to enhanced ALK activity are described.
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The spatial and temporal organization of ubiquitin networks
TL;DR: This work has shown how spatiotemporal regulation of ubiquitin species of different lengths and linkages in the nuclear factor-κB pathway, endocytic trafficking, protein degradation and DNA repair control diverse biological processes not only in the cell but also during the development of tissues and entire organisms.
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Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion
Camilla Englund,Christina E. Lorén,Caroline Grabbe,Gaurav K. Varshney,Fabienne Deleuil,Bengt Hallberg,Ruth H. Palmer +6 more
TL;DR: It is shown that Drosophila Alk is the receptor for Jeb in the developing visceral mesoderm, and that Jeb binding stimulates an Alk-driven, extracellular signal-regulated kinase-mediated signalling pathway, which results in the expression of the downstream gene duf—needed for muscle fusion.
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Functional roles of ubiquitin-like domain (ULD) and ubiquitin-binding domain (UBD) containing proteins
Caroline Grabbe,Ivan Dikic +1 more
TL;DR: Functional roles of ubiquitin-like domain (ULD) and ubiquitIn-binding domain (UBD) containing proteins are studied in order to better understand the role of EMTs in ubiquitination.