S
Silje H. Nordgard
Researcher at Oslo University Hospital
Publications - 6
Citations - 1395
Silje H. Nordgard is an academic researcher from Oslo University Hospital. The author has contributed to research in topics: Copy number analysis & Breast cancer. The author has an hindex of 5, co-authored 6 publications receiving 1198 citations. Previous affiliations of Silje H. Nordgard include University of Oslo & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Allele-specific copy number analysis of tumors
Peter Van Loo,Silje H. Nordgard,Silje H. Nordgard,Ole Christian Lingjærde,Hege G. Russnes,Inga H. Rye,Wei Sun,Victor J. Weigman,Peter Marynen,Anders Zetterberg,Bjørn Naume,Charles M. Perou,Anne Lise Børresen-Dale,Vessela N. Kristensen +13 more
TL;DR: A genome-wide map of allelic skewness in breast cancer is constructed, indicating loci where one allele is preferentially lost, whereas the other allele isPreferentially gained, and it is hypothesized that these alternative alleles have a different influence on breast carcinoma development.
Journal ArticleDOI
Methylation profiling with a panel of cancer related genes: association with estrogen receptor, TP53 mutation status and expression subtypes in sporadic breast cancer.
Jo Anders Rønneberg,Jo Anders Rønneberg,Thomas Fleischer,Thomas Fleischer,Hiroko K. Solvang,Silje H. Nordgard,Hege Edvardsen,Ivan Potapenko,Daniel Nebdal,Christian Daviaud,Ivo Gut,Ida Rashida Khan Bukholm,Bjørn Naume,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Jörg Tost,Vessela N. Kristensen,Vessela N. Kristensen +17 more
TL;DR: The results show that breast tumor expression subtypes harbor major epigenetic differences and tumors with similar gene expression profiles might belong to epigenetically different subtypes.
Journal ArticleDOI
Integrated study of copy number states and genotype calls using high-density SNP arrays
Wei Sun,Fred A. Wright,Zheng-Zheng Tang,Silje H. Nordgard,Peter Van Loo,Peter Van Loo,Peter Van Loo,Tianwei Yu,Vessela N. Kristensen,Charles M. Perou +9 more
TL;DR: A statistical framework to simultaneously dissect copy number states and genotypes using high-density SNP (single nucleotide polymorphism) arrays is proposed, which can successfully identify both types of copy number differences and produce high-quality genotype calls.
Journal ArticleDOI
Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival.
Victor J. Weigman,Hann Hsiang Chao,Andrey A. Shabalin,Xiaping He,Joel S. Parker,Silje H. Nordgard,Tatyana A. Grushko,Dezheng Huo,Chika Nwachukwu,Andrew B. Nobel,Vessela N. Kristensen,Vessela N. Kristensen,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Olufunmilayo I. Olopade,Charles M. Perou +15 more
TL;DR: In this article, the authors classified tumors according to gene expression subtypes and next identified subtype-associated DNA copy number aberrations (CNA) using a novel method called SWITCHdna, using a training set of 180 tumors and a validation set of 359 tumors.
Book ChapterDOI
Analyzing cancer samples with SNP arrays
Peter Van Loo,Peter Van Loo,Gro Nilsen,Silje H. Nordgard,Hans Kristian Moen Vollan,Hans Kristian Moen Vollan,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Vessela N. Kristensen,Vessela N. Kristensen,Vessela N. Kristensen,Ole Christian Lingjærde +11 more
TL;DR: This work applies the recently developed and further improved ASCAT (allele-specific copy number analysis of tumors) suite of tools to analyze SNP array data using data from a series of breast carcinomas as an example and describes how these ASCAT profiles visualize both copy number aberrations as well as copy-number-neutral events.