S
Silvana Balzar
Researcher at University of Pittsburgh
Publications - 33
Citations - 2939
Silvana Balzar is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Asthma & Eosinophil. The author has an hindex of 21, co-authored 33 publications receiving 2640 citations. Previous affiliations of Silvana Balzar include Anschutz Medical Campus & National Jewish Health.
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Journal ArticleDOI
Distinguishing severe asthma phenotypes: Role of age at onset and eosinophilic inflammation
TL;DR: Differentiating severe asthma by age at onset and presence or absence of eosinophils identifies phenotypes of asthma, which could benefit subsequent genetic and therapeutic studies.
Journal ArticleDOI
Mast Cell Phenotype, Location, and Activation in Severe Asthma: Data from the Severe Asthma Research Program
Silvana Balzar,Merritt L. Fajt,Suzy A. A. Comhair,Serpil C. Erzurum,Eugene R. Bleecker,William W. Busse,Mario Castro,Benjamin Gaston,Elliot Israel,Lawrence B. Schwartz,Douglas Curran-Everett,Charity G. Moore,Sally E. Wenzel +12 more
TL;DR: Severe asthma is associated with a predominance of MC(TC) in the airway submucosa and epithelium, and the data suggest an altered and active MC population contributes to SA pathology.
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Persistent wheezing in very young children is associated with lower respiratory inflammation.
Marzena E. Krawiec,Jay Y. Westcott,Hong Wei Chu,Silvana Balzar,John B. Trudeau,Lawrence B. Schwartz,Sally E. Wenzel +6 more
TL;DR: It is confirmed that inflammation is present in the airways of very young WC and may differ from patterns seen in adults with asthma.
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IL‐13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells
Kazuyuki Chibana,John B. Trudeau,A. T. Mustovitch,Haizhen Hu,Jing Zhao,Silvana Balzar,H. W. Chu,Sally E. Wenzel +7 more
TL;DR: In mouse and submerged human epithelial cells, Th2 cytokines inhibit expression of inducible nitric oxide synthase (iNOS), which contributes to asthma pathogenesis by limiting the arginine substrate available to NOS enzymes.
Journal ArticleDOI
Relationship of small airway chymase-positive mast cells and lung function in severe asthma.
TL;DR: The data suggest that induction of chymase-positive mast cells, particularly in the small airway outer wall/alveolar attachments region, may be protective for lung function in severe asthma.