M
Mario Castro
Researcher at University of Kansas
Publications - 396
Citations - 29097
Mario Castro is an academic researcher from University of Kansas. The author has contributed to research in topics: Asthma & Medicine. The author has an hindex of 80, co-authored 337 publications receiving 24012 citations. Previous affiliations of Mario Castro include North Central Cancer Treatment Group & Washington University in St. Louis.
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Journal ArticleDOI
Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program
Wendy C. Moore,Deborah A. Meyers,Sally E. Wenzel,W. Gerald Teague,Huashi Li,Xingnan Li,Ralph B. D'Agostino,Mario Castro,Douglas Curran-Everett,Anne M. Fitzpatrick,Benjamin Gaston,Nizar N. Jarjour,Ronald L. Sorkness,William J. Calhoun,Kian Fan Chung,Suzy A.A. Comhair,Raed A. Dweik,Elliot Israel,Stephen P. Peters,William W. Busse,Serpil C. Erzurum,Eugene R. Bleecker +21 more
TL;DR: Five distinct clinical phenotypes of asthma have been identified using an unsupervised hierarchical cluster analysis, which supports clinical heterogeneity in asthma and the need for new approaches for the classification of disease severity in asthma.
Journal ArticleDOI
Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma
Mario Castro,Jonathan Corren,Ian D. Pavord,Jorge Maspero,Sally E. Wenzel,Klaus F. Rabe,William W. Busse,Linda B. Ford,Lawrence Sher,J. Mark FitzGerald,Constance H. Katelaris,Yuji Tohda,Bingzhi Zhang,Heribert Staudinger,Gianluca Pirozzi,Nikhil Amin,Marcella Ruddy,Bolanle Akinlade,Asif Khan,Jingdong Chao,Renata Martincova,Neil M.H. Graham,Jennifer D. Hamilton,Brian N. Swanson,Neil Stahl,George D. Yancopoulos,Ariel Teper +26 more
TL;DR: Patients who received dupilumab had significantly lower rates of severe asthma exacerbation than those who received placebo, as well as better lung function and asthma control.
Journal ArticleDOI
Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials
Mario Castro,James Zangrilli,Michael E. Wechsler,Eric D. Bateman,Guy Brusselle,Philip G. Bardin,Kevin R. Murphy,Jorge Maspero,C.D. O'Brien,Stephanie Korn +9 more
TL;DR: These results support the use of reslizumab in patients with asthma and elevated blood eosinophil counts who are inadequately controlled on inhaled corticosteroid-based therapy.
Journal ArticleDOI
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
Wendy C. Moore,Eugene R. Bleecker,Douglas Curran-Everett,Serpil C. Erzurum,Bill T. Ameredes,Leonard B. Bacharier,William J. Calhoun,Mario Castro,Kian Fan Chung,Melissa P. Clark,Raed A. Dweik,Anne M. Fitzpatrick,Benjamin Gaston,Mark Hew,Iftikhar Hussain,Nizar N. Jarjour,Elliot Israel,Bruce D. Levy,James Murphy,Stephen P. Peters,W. Gerald Teague,Deborah A. Meyers,William W. Busse,Sally E. Wenzel,Sally E. Wenzel,Sally E. Wenzel +25 more
TL;DR: Severe asthma is characterized by abnormal lung function that is responsive to bronchodilators, a history of sinopulmonary infections, persistent symptoms, and increased health care utilization.
Journal ArticleDOI
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
Dara G. Torgerson,Dara G. Torgerson,Elizabeth J. Ampleford,Grace Y. Chiu,W. James Gauderman,Christopher R. Gignoux,Penelope E. Graves,Blanca E. Himes,Albert M. Levin,Rasika A. Mathias,Dana B. Hancock,Dana B. Hancock,Dana B. Hancock,James W. Baurley,Celeste Eng,Debra A. Stern,Juan C. Celedón,Nicholas Rafaels,Daniel Capurso,David V. Conti,Lindsey A. Roth,Manuel Soto-Quiros,Alkis Togias,Xingnan Li,Rachel A. Myers,Isabelle Romieu,Isabelle Romieu,David Van Den Berg,Donglei Hu,Nadia N. Hansel,Ryan D. Hernandez,Elliott Israel,Muhammad T. Salam,Joshua Galanter,Pedro C. Avila,Lydiana Avila,Jose R. Rodriquez-Santana,R. Chapela,William Rodríguez-Cintrón,Gregory B. Diette,N. Franklin Adkinson,Rebekah A. Abel,K. Ross,Min Shi,Mezbah U. Faruque,Georgia M. Dunston,Harold Watson,Vito J. Mantese,Serpil C. Ezurum,Liming Liang,Ingo Ruczinski,Jean G. Ford,Scott Huntsman,Kian Fan Chung,Hita Vora,Xia Li,William J. Calhoun,Mario Castro,Juan José Luis Sienra-Monge,Blanca Estela Del Río-Navarro,Klaus A. Deichmann,Andrea Heinzmann,Sally E. Wenzel,William W. Busse,William W. Busse,James E. Gern,Robert F. Lemanske,Terri H. Beaty,Eugene R. Bleecker,Benjamin A. Raby,Deborah A. Meyers,Stephanie J. London,Frank D. Gilliland,Esteban G. Burchard,Fernando D. Martinez,Scott T. Weiss,L. Keoki Williams,Kathleen C. Barnes,Carole Ober,Dan L. Nicolae +79 more
TL;DR: The results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma.