S
Silvia Fre
Researcher at PSL Research University
Publications - 31
Citations - 2336
Silvia Fre is an academic researcher from PSL Research University. The author has contributed to research in topics: Stem cell & Cellular differentiation. The author has an hindex of 13, co-authored 24 publications receiving 2028 citations. Previous affiliations of Silvia Fre include Curie Institute & Pierre-and-Marie-Curie University.
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Journal ArticleDOI
Notch signals control the fate of immature progenitor cells in the intestine
Silvia Fre,Mathilde Huyghe,Philippos Mourikis,Philippos Mourikis,Sylvie Robine,Daniel Louvard,Spyros Artavanis-Tsakonas,Spyros Artavanis-Tsakonas +7 more
TL;DR: By modulating Notch activity in the mouse intestine, this work directly implicates Notch signals in intestinal cell lineage specification and shows that Notch activation is capable of amplifying the intestinal progenitor pool while inhibiting cell differentiation.
Journal ArticleDOI
Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine
Silvia Fre,SK Pallavi,Mathilde Huyghe,Marick Laé,Klaus-Peter Janssen,Sylvie Robine,Spyros Artavanis-Tsakonas,Daniel Louvard +7 more
TL;DR: Modulating Notch activity in mice carrying either a loss- or a gain-of-function mutation of Wnt signaling reveals a previously unknown oncogenic potential of Notch signaling in colorectal tumorigenesis that is supported by the analysis of human tumors.
Journal ArticleDOI
Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure
Maria Elena Fernandez-Sanchez,Sandrine Barbier,Joanne Whitehead,Gaëlle Béalle,Aude Michel,Heldmuth Latorre-Ossa,Colette Rey,Laura Fouassier,Audrey Clapéron,Laura Brulle,Elodie Girard,Nicolas Servant,Thomas Rio-Frio,Hélène Marie,Sylviane Lesieur,Chantal Housset,Jean-Luc Gennisson,Mickael Tanter,Christine Ménager,Silvia Fre,Sylvie Robine,Emmanuel Farge +21 more
TL;DR: Mechanical activation of the tumorigenic β-catenin pathway suggests unexplored modes of tumour propagation based on mechanical signalling pathways in healthy epithelial cells surrounding the tumour, which may contribute to tumour heterogeneity.
Journal ArticleDOI
Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut.
Maia Chanrion,Inna Kuperstein,Cédric Barrière,Fatima El Marjou,David P. A. Cohen,Danijela Matic Vignjevic,Lev Stimmer,Perrine Paul-Gilloteaux,Ivan Bièche,Silvina Dos Reis Tavares,Giuseppe-Fulvio Boccia,Wulfran Cacheux,Didier Meseure,Silvia Fre,Loredana Martignetti,Patricia Legoix-Né,Elodie Girard,Luc Fetler,Emmanuel Barillot,Daniel Louvard,Andrei Zinovyev,Sylvie Robine +21 more
TL;DR: A computational network-based and experimental approaches are combined to create a mouse model that recapitulates the cellular features observed in invasive human colorectal tumours and confirms that Notch activation and p53 deletion have a synergistic effect in activating EMT-like processes.
Journal ArticleDOI
Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice.
Silvia Fre,Edouard Hannezo,Sanja Sale,Mathilde Huyghe,Daniel Lafkas,Holger Kissel,Angeliki Louvi,Jeffrey Greve,Daniel Louvard,Spyros Artavanis-Tsakonas,Spyros Artavanis-Tsakonas,Spyros Artavanis-Tsakonas +11 more
TL;DR: A new series of transgenic mice were generated that allowed this work to formally prove that Notch1 and Notch2 are specifically expressed in crypt stem cells, and a novel Notch reporter mouse, Hes1-EmGFPSAT, demonstrated exclusive Notch activity in Crypt stem cells and absorptive progenitors.