Sylvie Robine

TL;DR: This work shows a rapid, massive conversion of proliferative crypt cells into post-mitotic goblet cells after conditional removal of the common Notch pathway transcription factor CSL/RBP-J and indicates that γ-secretase inhibitors, developed for Alzheimer's disease, might be of therapeutic benefit in colorectal neoplastic disease.

TL;DR: Intestine-specific inactivation of ferroportin confirmed that it is critical for intestinal iron absorption and gave insight into hemochromatosis.

TL;DR: Transgenic mice bearing a tamoxifen‐dependent Cre recombinase (vil‐Cre‐ERT2) expressed under the control of the villin promoter were created to perform targeted spatiotemporally controlled somatic recombination of target genes in the mouse digestive epithelium.

TL;DR: By modulating Notch activity in the mouse intestine, this work directly implicates Notch signals in intestinal cell lineage specification and shows that Notch activation is capable of amplifying the intestinal progenitor pool while inhibiting cell differentiation.

TL;DR: An essential requirement of Wnt/β-catenin signaling for the maintenance of the intestinal epithelium in the adult organism is demonstrated, challenging attempts to target aberrant Wnt signaling as a new therapeutic strategy to treat colorectal cancer.