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Inna Kuperstein
Researcher at PSL Research University
Publications - 48
Citations - 3794
Inna Kuperstein is an academic researcher from PSL Research University. The author has contributed to research in topics: Systems biology & Biological network. The author has an hindex of 18, co-authored 47 publications receiving 2706 citations. Previous affiliations of Inna Kuperstein include French Institute of Health and Medical Research & Mines ParisTech.
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Journal ArticleDOI
Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer
Ana Catarina Costa,Ana Catarina Costa,Yann Kieffer,Yann Kieffer,Alix Scholer-Dahirel,Alix Scholer-Dahirel,Floriane Pelon,Floriane Pelon,Brigitte Bourachot,Brigitte Bourachot,Melissa Cardon,Melissa Cardon,Philémon Sirven,Philémon Sirven,Ilaria Magagna,Ilaria Magagna,Laetitia Fuhrmann,Charles Bernard,Charles Bernard,Claire Bonneau,Claire Bonneau,Maria Kondratova,Inna Kuperstein,Andrei Zinovyev,Anne-Marie Givel,Anne-Marie Givel,Maria Carla Parrini,Vassili Soumelis,Anne Vincent-Salomon,Fatima Mechta-Grigoriou,Fatima Mechta-Grigoriou +30 more
TL;DR: Four CAF subsets in breast cancer are characterized with distinct properties and levels of activation and CAF-S1 enhances the regulatory T cell capacity to inhibit T effector proliferation.
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Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0
Laurent Heirendt,Sylvain Arreckx,Thomas Pfau,Sebastián N. Mendoza,Anne Richelle,Almut Heinken,Hulda S. Haraldsdóttir,Jacek Wachowiak,Sarah M. Keating,Vanja Vlasov,Stefania Magnusdottir,Chiam Yu Ng,German Preciat,Alise Žagare,Siu Hung Joshua Chan,Maike K. Aurich,Catherine M. Clancy,Jennifer Modamio,John T. Sauls,Alberto Noronha,Aarash Bordbar,Benjamin Cousins,Diana C. El Assal,Luis Vitores Valcárcel,Iñigo Apaolaza,Susan Ghaderi,Masoud Ahookhosh,Marouen Ben Guebila,Andrejs Kostromins,Nicolas Sompairac,Hoai M. Le,Ding Ma,Yuekai Sun,Lin Wang,James T. Yurkovich,Miguel A.P. Oliveira,Phan Tu Vuong,Lemmer P. El Assal,Inna Kuperstein,Andrei Zinovyev,H. Scott Hinton,William A. Bryant,Francisco J. Aragón Artacho,Francisco J. Planes,Egils Stalidzans,Alejandro Maass,Santosh Vempala,Michael Hucka,Michael A. Saunders,Costas D. Maranas,Nathan E. Lewis,Thomas Sauter,Bernhard O. Palsson,Bernhard O. Palsson,Ines Thiele,Ronan M. T. Fleming,Ronan M. T. Fleming +56 more
TL;DR: This protocol provides an overview of all new features of the COBRA Toolbox and can be adapted to generate and analyze constraint-based models in a wide variety of scenarios.
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Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.
Inna Kuperstein,Kerensa Broersen,Kerensa Broersen,Iryna Benilova,Iryna Benilova,Iryna Benilova,Jef Rozenski,Wim Jonckheere,Wim Jonckheere,Maja Debulpaep,Maja Debulpaep,Annelies Vandersteen,Annelies Vandersteen,Ine M.J. Segers-Nolten,Kees van der Werf,Vinod Subramaniam,Dries Braeken,Geert Callewaert,Carmen Bartic,Carmen Bartic,Rudi D'Hooge,Ivo C. Martins,Ivo C. Martins,Frederic Rousseau,Frederic Rousseau,Joost Schymkowitz,Joost Schymkowitz,Bart De Strooper,Bart De Strooper +28 more
TL;DR: It is shown that small alterations in the Aβ42:Aβ40 ratio dramatically affect the biophysical and biological properties of the A β mixtures reflected in their aggregation kinetics, the morphology of the resulting amyloid fibrils and synaptic function tested in vitro and in vivo.
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Lipids revert inert Aβ amyloid fibrils to neurotoxic protofibrils that affect learning in mice
Ivo C. Martins,Inna Kuperstein,Hannah Wilkinson,Elke Maes,Mieke Vanbrabant,Wim Jonckheere,Patrick Van Gelder,Dieter Hartmann,Rudi D'Hooge,Bart De Strooper,Joost Schymkowitz,Frederic Rousseau +11 more
TL;DR: It is shown that natural lipids destabilize and rapidly resolubilize mature Aβ amyloid fibers and generate ‘backward’ Aβ protofibrils, which consist of a wide range of molecular masses, are toxic to primary neurons and cause memory impairment and tau phosphorylation in mouse.
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The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease.
Alberto Noronha,Jennifer Modamio,Yohan Jarosz,Elisabeth Guerard,Nicolas Sompairac,German Andres Preciat Gonzalez,Anna Dröfn Daníelsdóttir,Max Krecke,Diane Merten,Hulda S. Haraldsdóttir,Almut Heinken,Laurent Heirendt,Stefania Magnusdottir,Dmitry A. Ravcheev,Swagatika Sahoo,Piotr Gawron,Lucia Friscioni,Beatriz Garcia,Mabel Prendergast,Alberto Puente,Mariana Rodrigues,Akansha Roy,Mouss Rouquaya,Luca Wiltgen,Alise Žagare,Elisabeth John,Maren Krueger,Inna Kuperstein,Andrei Zinovyev,Reinhard Schneider,Ronan M. T. Fleming,Ronan M. T. Fleming,Ines Thiele +32 more
TL;DR: The VMH represents a novel, interdisciplinary database for data interpretation and hypothesis generation to the biomedical community and encapsulating current knowledge of human metabolism within five interlinked resources.