Silvia Minardi

TL;DR: A method is described that leverages the advantages of bottom-up and top-down strategies to incorporate proteins derived from the leukocyte plasma membrane into lipid nanoparticles that retained the versatility and physicochemical properties typical of liposomal formulations and enabled the selective and effective delivery of dexamethasone to inflamed tissues.

TL;DR: A high level of structural mimicry by the scaffold to the composition and structure of human osteogenic niche that translated to faster and more efficient osteoinduction in vivo is confirmed, suggesting such a biomaterial may have great utility in future clinical applications where bone regeneration is required.

TL;DR: It is shown that margination, which is almost absent when particles are suspended in a cell-free medium, is drastically enhanced by RBCs, with larger spherical/discoid particles being more effectively marginated both in vitro and in vivo.

TL;DR: A chondroitin sulfate‐based biomimetic scaffold is proposed that recapitulates the physicochemical features of the chondrogenic niche and retains MSC immunosuppressive potential in vitro, which correlated with a greater upregulation of genes involved in inflammatory cell apoptotic processes.

TL;DR: This review article addresses the various aspects of nano-biomaterials used in or being pursued for the purpose of promoting bone regeneration and aims to provide a conceptual framework to guide further exploration and inform future product development.