Silvia Rocchiccioli

TL;DR: An innovative drug-loaded nanocarrier with improved targeting properties based on the homotypic recognition of GBM cells is presented and it is demonstrated as Dox-CM-BNNTs are able to specifically target and kill G BM cells in vitro, leaving unaffected healthy brain cells, upon successful crossing an in vitro blood-brain barrier model.

TL;DR: A peptide coating able to bind transferrin on suitable pockets not involved in binding to TfR or iron is rationally designed by using an iterative multiscale-modeling approach coupled with quantitative structure-activity and relationship (QSAR) analysis and evolutionary algorithms, which leads to highly effective nanostructures.

TL;DR: RNA-dependent gene silencing, obtained against the putative targets with high selective and specific molecular tools, might be able to reverse a pathological drift and be suitable candidates for innovative therapeutic approaches.

TL;DR: This work has suggested a potential involvement of adenosine in the fibrotic lung disease processes, which are characterized by different degrees of inflammation and fibrosis and are of unknown etiology and burdened by lack of effective treatments in humans.

TL;DR: Preliminary data are promising for a possible identification of potential circulating markers of a cell state and in microvesicles there are several proteins that are involved in vesicle trafficking while in exosomes focal adhesion and ECM related factors are the most interesting.