S
Simbarashe Mabwe
Researcher at University of Cape Town
Publications - 17
Citations - 1107
Simbarashe Mabwe is an academic researcher from University of Cape Town. The author has contributed to research in topics: Tuberculosis & Mycobacterium tuberculosis. The author has an hindex of 11, co-authored 17 publications receiving 702 citations. Previous affiliations of Simbarashe Mabwe include TuBerculosis Vaccine Initiative.
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Journal ArticleDOI
Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination
Elisa Nemes,Hennie Geldenhuys,Virginie Rozot,Kathryn Tucker Rutkowski,Frances Ratangee,Nicole Bilek,Simbarashe Mabwe,Lebohang Makhethe,Mzwandile Erasmus,Asma Toefy,Humphrey Mulenga,Willem A. Hanekom,Steven G. Self,Linda-Gail Bekker,Ryall Robert P,Sanjay Gurunathan,Carlos A. DiazGranados,Peter Andersen,Ingrid Kromann,Thomas J. Evans,Ruth D. Ellis,Bernard Landry,David A. Hokey,Robert Hopkins,Ann M. Ginsberg,Thomas J. Scriba,Mark Hatherill +26 more
TL;DR: The rate of sustained QFT conversion, which may reflect sustained M. tuberculosis infection, was reduced by vaccination in a high‐transmission setting, and this finding may inform clinical development of new vaccine candidates.
Journal ArticleDOI
Optimization and Interpretation of Serial QuantiFERON Testing to Measure Acquisition of Mycobacterium tuberculosis Infection
Elisa Nemes,Virginie Rozot,Hennie Geldenhuys,Nicole Bilek,Simbarashe Mabwe,Deborah Abrahams,Lebohang Makhethe,Mzwandile Erasmus,Alana Keyser,Asma Toefy,Yolundi Cloete,Frances Ratangee,Thomas Blauenfeldt,Morten Ruhwald,Gerhard Walzl,Bronwyn Smith,Andre G. Loxton,Willem A. Hanekom,Jason R. Andrews,Maria Lempicki,Ruth D. Ellis,Ann M. Ginsberg,Mark Hatherill,Thomas J. Scriba +23 more
TL;DR: Implementation of optimized procedures and a more rigorous QuantiFERON‐TB conversion definition would allow more definitive detection of recent Mtb infection and potentially improve identification of those more likely to develop disease.
Journal ArticleDOI
Safety and immunogenicity of the novel tuberculosis vaccine ID93 + GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial
Adam Penn-Nicholson,Michele Tameris,Erica Smit,Tracey A. Day,Munyaradzi Musvosvi,Lakshmi Jayashankar,Julie Vergara,Simbarashe Mabwe,Nicole Bilek,H. Geldenhuys,Angelique Kany Kany Luabeya,Ruth D. Ellis,Ann M. Ginsberg,Willem A. Hanekom,Steven G. Reed,Rhea N. Coler,Thomas J. Scriba,Mark Hatherill +17 more
TL;DR: While cohort sample sizes in this phase 1 trial were small and results should be interpreted in context, these data support efficacy testing of two administrations of the lowest ID93 vaccine dose in tuberculosis endemic populations.
Journal ArticleDOI
Biomarker-guided tuberculosis preventive therapy (CORTIS): a randomised controlled trial.
Thomas J. Scriba,Andrew Fiore-Gartland,Adam Penn-Nicholson,Humphrey Mulenga,Stanley Kimbung Mbandi,Bhavesh Borate,Simon C Mendelsohn,Katie Hadley,Chris Hikuam,Masooda Kaskar,Munyaradzi Musvosvi,Nicole Bilek,Steven G. Self,Tom Sumner,Richard G. White,Mzwandile Erasmus,Lungisa Jaxa,Rodney Raphela,Craig Innes,William Brumskine,Andriëtte Hiemstra,Stephanus T. Malherbe,Razia Hassan-Moosa,Razia Hassan-Moosa,Michele Tameris,Gerhard Walzl,Kogieleum Naidoo,Kogieleum Naidoo,Gavin J. Churchyard,Mark Hatherill,Kesenogile Baepanye,Tshepiso Baepanye,Ken Clarke,Marelize Collignon,Audrey Dlamini,Candice Eyre,Tebogo Feni,Moogo Fikizolo,Phinda Galane,Thelma Goliath,Alia Gangat,Shirley Malefo-Grootboom,Elba Janse van Rensburg,Bonita Janse van Rensburg,Sophy Kekana,Marietjie Zietsman,Adrianne Kock,Israel Kunene,Aneessa Lakhi,Nondumiso Langa,Hilda Ledwaba,Marillyn Luphoko,Immaculate Mabasa,Dorah Mabe,Nkosinathi Mabuza,Molly Majola,Mantai Makhetha,Mpho Makoanyane,Blossom Makhubalo,Vernon Malay,Juanita Market,Selvy Matshego,Nontsikelelo Mbipa,Tsiamo Mmotsa,Sylvester Modipa,Samuel Mopati,Palesa Moswegu,Primrose Mothaga,Dorothy Muller,Grace Nchwe,Maryna Nel,Lindiwe Nhlangulela,Bantubonke Ntamo,Lawerence Ntoahae,Tedrius Ntshauba,Nomsa Sanyaka,Letlhogonolo Seabela,Pearl Selepe,Melissa Senne,MG Serake,Maria Thlapi,Vincent Tshikovhi,Lebogang Tswaile,Amanda van Aswegen,Lungile Mbata,Constance Takavamanya,Pedro Pinho,John Mdlulu,Marthinette Taljaard,Naydene Slabbert,Sharfuddin Sayed,Tanya Nielson,Ni Ni Sein,Dhineshree Govender,Tilagavathy Chinappa,Mbali Ignatia Zulu,Nonhle Bridgette Maphanga,Senzo Ralph Hlathi,Goodness Khanyisile Gumede,Thandiwe Yvonne Shezi,Jabulisiwe Lethabo Maphanga,Zandile Patrica Jali,Thobelani Cwele,Nonhlanhla Zanele Elsie Gwamanda,Celaphiwe Dlamini,Zibuyile Phindile Penlee Sing,Ntombozuko Gloria Ntanjana,Sphelele Simo Nzimande,Siyabonga Mbatha,Bhavna Maharaj,Atika Moosa,Cara-Mia Corris,Fazlin Kafaar,Hennie Geldenhuys,Angelique Kany Kany Luabeya,Justin Shenje,Natasja Botes,Susan Rossouw,Hadn Africa,Bongani Diamond,Samentra Braaf,Sonia Stryers,Alida Carstens,Ruwiyda Jansen,Simbarashe Mabwe,Roxane Herling,Ashley Veldsman,Lebohgang Makhete,Marcia Steyn,Sivuyile Buhlungu,Margareth Erasmus,Ilse Davids,Patiswa Plaatjie,Alessandro Companie,Frances Ratangee,Helen Veldtsman,Christel Petersen,Charmaine Abrahams,Miriam Moses,Xoliswa Kelepu,Yolande Gregg,Liticia Swanepoel,Nomsitho Magawu,Nompumelelo Cetywayo,Lauren Mactavie,Habibullah Valley,Elizabeth Filander,Nambitha Nqakala,Elizna Maasdorp,Justine Khoury,Belinda Kriel,Bronwyn Smith,Liesel Muller,Susanne Tonsing,Andre G. Loxton,Petri Ahlers,Marika Flinn,Eva Chung,Michelle Chung,Alicia Sato +159 more
TL;DR: In this article, the authors tested performance of a transcriptomic signature of tuberculosis (RISK11) and efficacy of signature-guided preventive therapy in parallel, using a hybrid three-group study design.
Journal ArticleDOI
Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial
Michele Tameris,Helen Mearns,Adam Penn-Nicholson,Yolande Gregg,Nicole Bilek,Simbarashe Mabwe,Hennie Geldenhuys,Justin Shenje,Angelique Kany Kany Luabeya,Ingrid Murillo,Juana Doce,Nacho Aguilo,Nacho Aguilo,Dessislava Marinova,Dessislava Marinova,Eugenia Puentes,Esteban M. Rodríguez,Jesús Gonzalo-Asensio,Jesús Gonzalo-Asensio,Bernard Fritzell,Jelle Thole,Carlos Martin,Carlos Martin,Thomas J. Scriba,Mark Hatherill,Hadn Africa,Denis Arendsen,Natasja Botes,Yolundi Cloete,Marwou de Kock,Margaret Erasmus,Lungisa Jack,Fazlin Kafaar,Xoliswa Kalepu,Nondumiso Khomba,Sandra Kruger,Thelma Leopeng,Lebohang Makhethe,Angelique Mouton,Humphrey Mulenga,Munyaradzi Musvosvi,Julia Noble,Fajwa Opperman,Tim Reid,Susan Rossouw,Constance Schreuder,Erica Smit,Marcia Steyn,Petrus Tyambethu,Elma Van Rooyen,Ashley Veldsman +50 more
TL;DR: The safety and immunogenicity of the live-attenuated Mycobacterium tuberculosis vaccine candidate MTBVAC in adults and infants in a region where transmission of tuberculosis is very high was assessed.