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Adam Penn-Nicholson
Researcher at University of Cape Town
Publications - 68
Citations - 3473
Adam Penn-Nicholson is an academic researcher from University of Cape Town. The author has contributed to research in topics: Tuberculosis & Medicine. The author has an hindex of 22, co-authored 58 publications receiving 2498 citations. Previous affiliations of Adam Penn-Nicholson include Case Western Reserve University & Foundation for Innovative New Diagnostics.
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Journal ArticleDOI
A blood RNA signature for tuberculosis disease risk: a prospective cohort study.
Daniel E. Zak,Adam Penn-Nicholson,Thomas J. Scriba,Ethan G. Thompson,Sara Suliman,Lynn M. Amon,Hassan Mahomed,Mzwandile Erasmus,Wendy Whatney,Gregory D. Hussey,Deborah Abrahams,Fazlin Kafaar,Tony Hawkridge,Suzanne Verver,E. Jane Hughes,Martin O. C. Ota,Jayne S. Sutherland,Rawleigh Howe,Hazel M. Dockrell,W. Henry Boom,Bonnie Thiel,Tom H. M. Ottenhoff,Harriet Mayanja-Kizza,Amelia C. Crampin,Katrina Downing,Mark Hatherill,Joe Valvo,Smitha Shankar,Shreemanta K. Parida,Stefan H. E. Kaufmann,Gerhard Walzl,Alan Aderem,Willem A. Hanekom +32 more
TL;DR: The whole blood tuberculosis risk signature prospectively identified people at risk of developing active tuberculosis, opening the possibility for targeted intervention to prevent the disease.
Journal ArticleDOI
Biology of CCR5 and its role in HIV infection and treatment
TL;DR: The effects that targeting CCR5 may have on host defenses in individuals with immunity already compromised by HIV infection are explored.
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T-cell activation is an immune correlate of risk in BCG vaccinated infants
Helen A. Fletcher,Helen A. Fletcher,Margaret A Snowden,Bernard Landry,Wasima Rida,Iman Satti,Stephanie A. Harris,Magali Matsumiya,Rachel Tanner,Matthew K. O'Shea,Veerabadran Dheenadhayalan,Leah Bogardus,Lisa Stockdale,Lisa Stockdale,Leanne Marsay,Agnieszka Chomka,Rachel Harrington-Kandt,Zita-Rose Manjaly-Thomas,Vivek Naranbhai,Elena Stylianou,Fatoumatta Darboe,Adam Penn-Nicholson,Elisa Nemes,Mark Hatherill,Gregory D. Hussey,Hassan Mahomed,Michele Tameris,J. Bruce McClain,Thomas G. Evans,Willem A. Hanekom,Thomas J. Scriba,Helen McShane +31 more
TL;DR: A case–control analysis to identify immune correlates of TB disease risk in Bacille Calmette–Guerin immunized infants from the MVA85A efficacy trial found that activated HLA-DR+ CD4+ T cells associates with increased TB diseaserisk.
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Comparing the Ex Vivo Fitness of CCR5-Tropic Human Immunodeficiency Virus Type 1 Isolates of Subtypes B and C
Sarah C. Ball,Awet Abraha,Kalonji R. Collins,Andre J. Marozsan,Heather A Baird,Miguel E. Quiñones-Mateu,Adam Penn-Nicholson,Michael G. Murray,Nathalie Richard,Michael A. Lobritz,Peter A. Zimmerman,Tatsuyoshi Kawamura,Andrew Blauvelt,Eric J. Arts +13 more
TL;DR: It is suggested that subtype B and C HIV-1 may be transmitted with equal efficiency but that sub type C isolates may be less fit following initial infection and may lead to slower disease progression.
Journal ArticleDOI
Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis
Sara Suliman,Ethan G. Thompson,Jayne S. Sutherland,January Weiner rd,Martin O. C. Ota,Smitha Shankar,Adam Penn-Nicholson,Adam Penn-Nicholson,Bonnie Thiel,Mzwandile Erasmus,Mzwandile Erasmus,Jeroen Maertzdorf,Fergal J. Duffy,Philip C. Hill,E. Jane Hughes,E. Jane Hughes,Kim Stanley,Katrina Downing,Katrina Downing,Michelle Fisher,Michelle Fisher,Joe Valvo,Shreemanta K. Parida,Gian D. van der Spuy,Gian D. van der Spuy,Gerard Tromp,Gerard Tromp,Ifedayo M. O. Adetifa,Simon Donkor,Rawleigh Howe,Harriet Mayanja-Kizza,W. Henry Boom,Hazel M. Dockrell,Tom H. M. Ottenhoff,Mark Hatherill,Mark Hatherill,Alan Aderem,Willem A. Hanekom,Willem A. Hanekom,Thomas J. Scriba,Thomas J. Scriba,Stefan H. E. Kaufmann,Daniel E. Zak,Gerhard Walzl,Gerhard Walzl +44 more
TL;DR: A simple whole blood‐based PCR test to predict TB in recently exposed household contacts from diverse African populations has potential for implementation in national TB contact investigation programs.