S
Simon Baumberg
Researcher at University of Leeds
Publications - 66
Citations - 2105
Simon Baumberg is an academic researcher from University of Leeds. The author has contributed to research in topics: Bacillus subtilis & Escherichia coli. The author has an hindex of 26, co-authored 66 publications receiving 2035 citations.
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Journal ArticleDOI
Inducible erythromycin resistance in staphlyococci is encoded by a member of the ATP‐binding transport super‐gene family
TL;DR: The deduced sequence of the 488‐amino‐acid protein (MsrA) revealed the presence of two ATP‐binding motifs homologous to those of a family of transport‐related proteins from Gram‐negative bacteria and eukaryotic cells, including the P‐glycoprotein responsible for multidrug resistance.
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Transcriptional activation of the pathway-specific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor
Gabriel C. Uguru,Karen E. Stephens,Jonathan A. Stead,Jane E. Towle,Simon Baumberg,Kenneth J. McDowall +5 more
TL;DR: Findings provide further evidence that the path leading to the expression of pathway‐specific activators of antibiotic biosynthesis genes in disparate Streptomyces may share evolutionarily conserved components in at least some cases, and suggests that the regulation of streptomycin production, which serves an important paradigm, may be more complex than represented by current models.
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Sequence and transcriptional analysis of the nourseothricin acetyltransferase-encoding gene nat1 from Streptomyces noursei.
TL;DR: The nucleotide (nt) sequence of nat1, a gene encoding nourseothricin (Nc) acetyltransferase (AT) from Streptomyces noursei, and its transcriptional start point (tsp) is determined.
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Purification and initial characterization of AhrC: the regulator of arginine metabolism genes in Bacillus subtilis
TL;DR: The data are consistent with the binding of a single hexamer of AhrC to argCO1 via four of its subunits, possibly allowing the remaining two subunits to bind at argCO2 in vivo forming a repression loop similar to those observed for the E coli Lac repressor.
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Identification of a chromosomally encoded abc-transport system with which the staphylococcal erythromycin exporter msra may interact
TL;DR: Results indicate that the chromosomes of S. hominis and S. aureus contain sequences encoding a potential TM protein with which MsrA might interact.