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Simon C. Chow
Researcher at McGill University Health Centre
Publications - 9
Citations - 1385
Simon C. Chow is an academic researcher from McGill University Health Centre. The author has contributed to research in topics: Metastasis & Cell adhesion. The author has an hindex of 7, co-authored 9 publications receiving 1058 citations. Previous affiliations of Simon C. Chow include McGill University.
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Journal ArticleDOI
Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis
Jonathan Cools-Lartigue,Jonathan Spicer,Braedon McDonald,Stephen Gowing,Simon C. Chow,Betty Giannias,Paul Kubes,Lorenzo E. Ferri +7 more
TL;DR: It is reported that circulating tumor cells become trapped within NETs in vitro under static and dynamic conditions and NETs are identified as potential therapeutic targets in the context of systemic infection.
Journal ArticleDOI
Neutrophils promote liver metastasis via Mac-1-mediated interactions with circulating tumor cells.
Jonathan Spicer,Braedon McDonald,Jonathan Cools-Lartigue,Simon C. Chow,Betty Giannias,Paul Kubes,Lorenzo E. Ferri +6 more
TL;DR: In vivo models of metastasis are used to show a novel role for neutrophils in the early adhesive steps of liver metastasis and promote cancer cell adhesion within liver sinusoids and, thereby, influence metastasis.
Journal ArticleDOI
Gram negative bacteria increase non-small cell lung cancer metastasis via Toll-like receptor 4 activation and mitogen-activated protein kinase phosphorylation.
Simon C. Chow,Stephen Gowing,Jonathan Cools-Lartigue,Crystal B. Chen,Julie Bérubé,Hee-Won Yoon,Carlos H. F. Chan,Mathieu Rousseau,Betty Giannias,Lucie Roussel,Salman T. Qureshi,Simon Rousseau,Lorenzo E. Ferri +12 more
TL;DR: It is demonstrated that NSCLC cells have increased in vivo adhesion to hepatic sinusoids after coincubation with gram negative bacteria, and TLR4 represents a potential therapeutic target to help prevent severe postoperative infection driven cancer metastasis.
Journal ArticleDOI
Lipopolysaccharide-induced toll-like receptor 4 signaling enhances the migratory ability of human esophageal cancer cells in a selectin-dependent manner
Mathieu Rousseau,Rich Yi-Chen Hsu,Jonathan Spicer,Braedon McDonald,Carlos H. F. Chan,Rushika Perera,Betty Giannias,Simon C. Chow,Simon Rousseau,Simon Law,Lorenzo E. Ferri,Lorenzo E. Ferri +11 more
TL;DR: LPS can increase the migratory ability of human esophageal cancer cells by increasing their adhesive properties through TLR4 signaling and selectin ligands.
Proceedings ArticleDOI
Abstract 2972: Neutrophil extracellular traps sequester circulating tumor cellsin vitroand in a murine model of metastasis
Jonathan Cools-Lartigue,Jonathan Spicer,Braedon McDonald,Simon C. Chow,Paul Kubes,Lorenzo E. Ferri +5 more
TL;DR: Neutrophil extracellular trap formation is associated with increased adherence and capture of cancer cells in both static and dynamic conditions, suggesting a novel mechanism by which neutrophils may promote cancer progression.