J
Jonathan Cools-Lartigue
Researcher at McGill University Health Centre
Publications - 107
Citations - 4331
Jonathan Cools-Lartigue is an academic researcher from McGill University Health Centre. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 20, co-authored 76 publications receiving 3112 citations. Previous affiliations of Jonathan Cools-Lartigue include Memorial Sloan Kettering Cancer Center & McGill University.
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Journal ArticleDOI
Targeting potential drivers of COVID-19: Neutrophil extracellular traps.
Betsy J. Barnes,José M. Adrover,Amelia Baxter-Stoltzfus,Alain C. Borczuk,Jonathan Cools-Lartigue,James M. Crawford,Juliane Daßler-Plenker,Philippe Guerci,Caroline Huynh,Jason S. Knight,Massimo Loda,Mark R. Looney,Florencia McAllister,Roni F. Rayes,Stéphane Renaud,Simon Rousseau,Steven P. Salvatore,Robert E. Schwartz,Jonathan Spicer,Christian C. Yost,Andrew G. Weber,Yu Zuo,Mikala Egeblad +22 more
TL;DR: Autopsy results and literature are presented supporting the hypothesis that neutrophil extracellular traps (NETs) may contribute to organ damage and mortality in COVID-19, and existing drugs that target NETs, although unspecific, may benefit CO VID-19 patients.
Journal ArticleDOI
Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis
Jonathan Cools-Lartigue,Jonathan Spicer,Braedon McDonald,Stephen Gowing,Simon C. Chow,Betty Giannias,Paul Kubes,Lorenzo E. Ferri +7 more
TL;DR: It is reported that circulating tumor cells become trapped within NETs in vitro under static and dynamic conditions and NETs are identified as potential therapeutic targets in the context of systemic infection.
Journal ArticleDOI
A systematic review of the effects of resident duty hour restrictions in surgery: impact on resident wellness, training, and patient outcomes.
Najma Ahmed,Katharine S. Devitt,Itay Keshet,Jonathan Spicer,Kevin Imrie,Liane S. Feldman,Jonathan Cools-Lartigue,Ahmed Kayssi,Nir Lipsman,Maryam Elmi,Abhaya V. Kulkarni,Chris Parshuram,Todd G. Mainprize,Richard Warren,Paola Fata,M. Sean Gorman,Stan Feinberg,James T. Rutka +17 more
TL;DR: Recent RDH changes are not consistently associated with improvements in resident well-being, and have negative impacts on patient outcomes and performance on certification examinations.
Journal ArticleDOI
Neutrophils promote liver metastasis via Mac-1-mediated interactions with circulating tumor cells.
Jonathan Spicer,Braedon McDonald,Jonathan Cools-Lartigue,Simon C. Chow,Betty Giannias,Paul Kubes,Lorenzo E. Ferri +6 more
TL;DR: In vivo models of metastasis are used to show a novel role for neutrophils in the early adhesive steps of liver metastasis and promote cancer cell adhesion within liver sinusoids and, thereby, influence metastasis.
Journal ArticleDOI
Neutrophil extracellular traps sequester circulating tumor cells via β1-integrin mediated interactions.
Sara Najmeh,Jonathan Cools-Lartigue,Roni F. Rayes,Stephen Gowing,Phil Vourtzoumis,Betty Giannias,Julie Bérubé,Simon Rousseau,Lorenzo E. Ferri,Jonathan Spicer +9 more
TL;DR: Light is shed on the first molecular mechanism by which NETs can trap circulating tumor cells (CTCs) and sheds light on the main cause of cancer death, broadening the understanding of this process.