S
Simon Rousseau
Researcher at McGill University
Publications - 96
Citations - 8121
Simon Rousseau is an academic researcher from McGill University. The author has contributed to research in topics: Cystic fibrosis & MAPK/ERK pathway. The author has an hindex of 34, co-authored 90 publications receiving 6851 citations. Previous affiliations of Simon Rousseau include University of Dundee & Laval University.
Papers
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Journal ArticleDOI
p38 MAP-kinases pathway regulation, function and role in human diseases.
Ana Cuenda,Simon Rousseau +1 more
TL;DR: The p38MAPK pathway is a key regulator of pro-inflammatory cytokines biosynthesis at the transcriptional and translational levels, which makes different components of this pathway potential targets for the treatment of autoimmune and inflammatory diseases.
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Targeting potential drivers of COVID-19: Neutrophil extracellular traps.
Betsy J. Barnes,José M. Adrover,Amelia Baxter-Stoltzfus,Alain C. Borczuk,Jonathan Cools-Lartigue,James M. Crawford,Juliane Daßler-Plenker,Philippe Guerci,Caroline Huynh,Jason S. Knight,Massimo Loda,Mark R. Looney,Florencia McAllister,Roni F. Rayes,Stéphane Renaud,Simon Rousseau,Steven P. Salvatore,Robert E. Schwartz,Jonathan Spicer,Christian C. Yost,Andrew G. Weber,Yu Zuo,Mikala Egeblad +22 more
TL;DR: Autopsy results and literature are presented supporting the hypothesis that neutrophil extracellular traps (NETs) may contribute to organ damage and mortality in COVID-19, and existing drugs that target NETs, although unspecific, may benefit CO VID-19 patients.
Journal ArticleDOI
p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells.
TL;DR: The results indicate that the p38 pathway conveys the VEGF signal to microfilaments inducing rearrangements of the actin cytoskeleton that regulate cell migration, and may thus be an important regulator of angiogenesis.
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Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta.
S Giroux,Michel J. Tremblay,D Bernard,J F Cardin-Girard,S Aubry,L Larouche,Simon Rousseau,Jacques Huot,Jacques Landry,Lucie Jeannotte,Jean Charron +10 more
TL;DR: These findings provide genetic evidence that establishes the unique role played by Mek1 in signal transduction and suggest that mek1 function is required for normal response to angiogenic signals that might promote vascularization of the labyrinthine region of the placenta.
Journal ArticleDOI
Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase.
Simon Rousseau,François Houle,Helen Kotanides,Larry Witte,Johannes Waltenberger,Jacques Landry,Jacques Huot +6 more
TL;DR: It is concluded that VEGFR2 mediates the physiological effect of VEGF on cell migration and that two independent pathways downstream of V EGFR2 regulate actin-based motility.