S
Simon J. Williams
Researcher at Australian National University
Publications - 60
Citations - 2928
Simon J. Williams is an academic researcher from Australian National University. The author has contributed to research in topics: Effector & Gene. The author has an hindex of 22, co-authored 50 publications receiving 2145 citations. Previous affiliations of Simon J. Williams include Flinders University & University of Queensland.
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Journal ArticleDOI
NAD+ cleavage activity by animal and plant TIR domains in cell death pathways
S. Horsefield,H. Burdett,Xiaoxiao Zhang,Xiaoxiao Zhang,M.K. Manik,Yun Shi,J. Chen,J. Chen,Tiancong Qi,Jonathan Gilley,Jonathan Gilley,Jhih Siang Lai,M. Rank,Lachlan W. Casey,W. Gu,Daniel J. Ericsson,G. Foley,R.O. Hughes,Todd Bosanac,Mark von Itzstein,John P. Rathjen,Jeffrey D. Nanson,Mikael Bodén,Ian B. Dry,Simon J. Williams,Brian J. Staskawicz,Michael P. Coleman,Michael P. Coleman,Thomas Ve,Thomas Ve,Peter N. Dodds,Bostjan Kobe +31 more
TL;DR: NAD depletion as pathogen response One way that plants respond to pathogen infection is by sacrificing the infected cells, and Toll/interleukin-1 receptor (TIR) domains cleave the metabolic cofactor nicotinamide adenine dinucleotide (NAD+) as part of their cell-death signaling in response to pathogens.
Journal ArticleDOI
Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation.
Maud Bernoux,Thomas Ve,Simon J. Williams,Christopher Warren,Danny M. Hatters,Eugene Valkov,Xiaoxiao Zhang,Jeffrey G. Ellis,Bostjan Kobe,Peter N. Dodds +9 more
TL;DR: Analysis of the structure combined with site-directed mutagenesis suggests that self-association is a requirement for immune signaling and reveals distinct surface regions involved in self-Association, signaling, and autoregulation.
Journal ArticleDOI
Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor
Simon J. Williams,Kee Hoon Sohn,Kee Hoon Sohn,Li Wan,Maud Bernoux,Panagiotis F. Sarris,Cécile Segonzac,Cécile Segonzac,Thomas Ve,Yan Ma,Simon B. Saucet,Daniel J. Ericsson,Lachlan W. Casey,Thierry G. A. Lonhienne,Donald J. Winzor,Xiaoxiao Zhang,Anne Coerdt,Jane E. Parker,Peter N. Dodds,Bostjan Kobe,Jonathan D. G. Jones +20 more
TL;DR: Crystal structures of the N-terminal Toll–interleukin-1 receptor/resistance (TIR) domains of RPS4 and RRS1, individually and as a heterodimeric complex reveal a conserved TIR/TIR interaction interface, and show that TIR domain heterodimization is required to form a functional RPS1/RPS4 effector recognition complex.
Journal ArticleDOI
Emerging Insights into the Functions of Pathogenesis-Related Protein 1
TL;DR: The current status of PR-1 proteins is reviewed and how recent advances shed light on putative roles for these enigmatic proteins are discussed.
Journal ArticleDOI
An Autoactive Mutant of the M Flax Rust Resistance Protein Has a Preference for Binding ATP, Whereas Wild-Type M Protein Binds ADP
Simon J. Williams,Pradeep Sornaraj,Emma deCourcy-Ireland,R. Ian Menz,Bostjan Kobe,Jeffrey G. Ellis,Peter N. Dodds,Peter A. Anderson +7 more
TL;DR: Data provide direct evidence supporting a model of R protein function in which the "off" R protein binds ADP and activation of Rprotein defense signaling involves the exchange of ADP for ATP.