Simon Pan

TL;DR: It is found that neuronal IL-33 instructs microglial engulfment of the extracellular matrix (ECM) and that its loss leads to impaired ECM engulfment and a concomitant accumulation of ECM proteins in contact with synapses, which define a cellular mechanism through which microglia regulate experience-dependent synapse remodeling and promote memory consolidation.

TL;DR: Bidirectional manipulation of myelin plasticity functionally affects behavior and neurophysiology, which suggests that neural activity during fear learning instructs the formation of new myelin, which in turn supports the consolidation and/or retrieval of remote fear memories.

TL;DR: Pan and Chan discuss the role of myelinating glia in axonal development and the impact of demyelination on axon degeneration.

TL;DR: Balancing oligodendrocyte-intrinsic programs of myelin supply with axonal demand is essential for correct myelin targeting in vivo and highlight potential liabilities of strongly promoting oligodENDrogenesis.

TL;DR: Functional resilience to input loss beyond pre-existing mechanisms in control retina is demonstrated and evidence for slower temporal filters and expanded receptive field surrounds, derived mainly from inhibitory inputs is found.