S
Simon Rothenfusser
Researcher at Ludwig Maximilian University of Munich
Publications - 68
Citations - 10997
Simon Rothenfusser is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: CpG site & CpG Oligodeoxynucleotide. The author has an hindex of 35, co-authored 62 publications receiving 10348 citations. Previous affiliations of Simon Rothenfusser include University of Massachusetts Medical School & Heidelberg University.
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Journal ArticleDOI
Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides
Veit Hornung,Simon Rothenfusser,Stefanie Britsch,Anne Krug,Bernd Jahrsdörfer,Thomas Giese,Stefan Endres,Gunther Hartmann +7 more
TL;DR: Evidence is provided that PDC and B cells, but not monocytes, NK cells, or T cells, are primary targets of CpG ODN in peripheral blood.
Journal ArticleDOI
Identification of CpG oligonucleotide sequences with high induction of IFN‐α/β in plasmacytoid dendritic cells
Anne Krug,Simon Rothenfusser,Veit Hornung,Bernd Jahrsdörfer,Susan Blackwell,Zuhair K. Ballas,Stefan Endres,Arthur M. Krieg,Gunther Hartmann +8 more
TL;DR: It is demonstrated that particular CpG ODN sequences exist which, due to high IFN‐α/β induction in PDC, induce a set of immune responses typical for viral infection.
Journal ArticleDOI
Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12.
Anne Krug,Andreas Towarowski,Stefanie Britsch,Simon Rothenfusser,Veit Hornung,Robert Bals,Thomas Giese,Hartmut Engelmann,Stefan Endres,Arthur M. Krieg,Gunther Hartmann +10 more
TL;DR: It is revealed that IL‐12 p70 production by PDC is under strict control of two signals, an adequate exogenous microbial stimulus such as CpG ODN, and CD40L provided endogenously by activatedT cells.
Journal ArticleDOI
Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40L to induce high amounts of IL-12
Andreas Towarowski,Anne Krug,Stefanie Britsch,Simon Rothenfusser,Veit Hornung,R. Bals,Thomas Giese,H. Engelmann,S. Endres,Arthur M. Krieg,Gunther Hartmann +10 more
TL;DR: It is revealed that IL-12 p70 production by PDC is under strict control of two signals, an adequate exogenous microbial stimulus such as CpG ODN, and CD40L provided endogenously by activated T cells.
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Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1|[beta]| production
Hendrik Poeck,Michael Bscheider,Olaf Gross,Olaf Gross,Katrin Finger,Susanne Roth,Manuele Rebsamen,Nicole Hannesschläger,Martin Schlee,Simon Rothenfusser,Winfried Barchet,Hiroki Kato,Shizuo Akira,Satoshi Inoue,Satoshi Inoue,Stefan Endres,Christian Peschel,Gunther Hartmann,Veit Hornung,Jürgen Ruland +19 more
TL;DR: The results identify the CARD9–Bcl-10 module as an essential component of the RIG-I-dependent proinflammatory response and establish Rig-I as a sensor able to activate the inflammasome in response to certain RNA viruses.